51307-04-1

Basic information

• Product Name: 2,4-Pentanedione, 1,5-diphenyl-
• Synonyms: 1,5-diphenyl-pentane-2,4-dione;2,4-Pentanedione,1,5-diphenyl;dibenzoylmethane;1,5-Diphenyl-pentan-2,4-dion;1,3-dibenzyl-1,3-propanedione;1,5-diphenyl-2,4-pentanedione
• CAS NO: 51307-04-1
• Molecular Formula: C17H16O2
• Molecular Weight: 252.313
• Mol File: 51307-04-1.mol

Chemical Properties

• CAS DataBase Reference: 2,4-Pentanedione, 1,5-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Pentanedione, 1,5-diphenyl-(51307-04-1)
• EPA Substance Registry System: 2,4-Pentanedione, 1,5-diphenyl-(51307-04-1)

Safety Data

• Hazardous Substances Data: 51307-04-1(Hazardous Substances Data)

Usage

Uses

Used in Chemical Production:
2,4-Pentanedione, 1,5-diphenylis used as a complexing agent for metal ions, enabling the production of various metal complexes and coordination compounds. Its ability to form stable complexes with metal ions makes it a valuable component in the synthesis of catalysts, dyes, and other specialty chemicals.
Used in Pharmaceutical Industry:
2,4-Pentanedione, 1,5-diphenylis used as a precursor in the synthesis of pharmaceuticals. Its reactivity and compatibility with other chemical groups make it a suitable starting material for the development of new drug molecules. Its involvement in the synthesis of heterocycles further expands its potential applications in the pharmaceutical sector.
Used in Dye Production:
2,4-Pentanedione, 1,5-diphenylis used as a key intermediate in the production of dyes. Its ability to form stable complexes with metal ions contributes to the development of dyes with improved color properties and stability. This makes it an essential component in the dye manufacturing process.
Used as a Flavoring Agent in Food Products:
2,4-Pentanedione, 1,5-diphenylis used as a flavoring agent in food products due to its unique taste and aroma. Its mild irritant properties contribute to the enhancement of flavors in various food items, making it a valuable ingredient in the food industry.
However, it is important to note that 2,4-Pentanedione, 1,5-diphenylshould be handled with care due to its mild irritant properties. Proper safety measures should be taken during its production, storage, and use to minimize potential health risks.

Upstream product

• 504-64-3 carbon suboxide 
• 766-04-1 benzyllithium 
• 1007-32-5 benzyl ethyl ketone 
• 141-78-6 ethyl acetate 
• 123-54-6 acetylacetone 
• 103-80-0 phenylacetyl chloride 
• 101-97-3 Ethyl 2-phenylethanoate 
• 103-79-7 1-phenyl-acetone 
• 156-06-9 2-oxo-3-(phenyl)propionic acid 
• 109839-21-6 3-phenyl-2,4-hexanedione 
• 20268-21-7 (E)-2-phenylacetaldehyde oxime 
• 300-57-2 allylbenzene 
• 161151-98-0 3,5-dibenzyl-4,5-dihydroisoxazole 
• 161152-00-7 1,5-diphenyl-4-hydroxy-pentan-2-one 

Downstream Products

• 205116-63-8 3-Dimethylaminomethylene-1,5-diphenyl-pentane-2,4-dione 
• 1450605-92-1 5-amino-3-phenylmethylisoquinolin-1-one 
• 1450605-82-9 5-nitro-3-phenylmethylisoquinolin-1-one 
• 1450605-72-7 5-nitro-3-phenylmethylisocoumarin 
• 1036388-86-9 (5,14-dihydro-6,8,15,17-tetrabenzyldibenzo[b,i][1,4,8,11]tetracyclodecine)nickel(II) 
• 259228-88-1 (R,R)-1,5-diphenyl-2,4-pentanediol cyclic sulfate 
• 135943-83-8 (2S,4S)-1,5-diphenyl-2,4-pentanediol 
• 135943-84-9 (2R,4R)-1,5-diphenyl-2,4-pentanediol 
• 51307-23-4 1,5-Diphenyl-3-oximino-2,4-pentandion 
• 19311-79-6 1-methyl-3,5-diphenyl-1H-pyrazole 
• 107772-71-4 3,5-dibenzyl-pyrazole-1-carboxylic acid amide 

Relevant articles and documents

One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs

Poly(ADP-ribose)polymerase-1 (PARP-1) is an important target for drug design for several therapeutic applications. 5-Aminoisoquinolin-1-one (5-AIQ) is a highly water-soluble lead compound; synthetic routes to 3-substituted analogues were explored. Tandem Hurtley coupling of β-diketones with 2-bromo-3-nitrobenzoic acid, retro-Claisen acyl cleavage and cyclisation gave the corresponding 3-substituted 5-nitroisocoumarins. Treatment with ammonia at high temperature and reduction with tin(II) chloride gave eleven target 3-substituted 5-AIQs, which were all soluble in water (>1% w/v) as their HCl salts. Most were more potent than 5-AIQ as inhibitors of PARP-1 and of PARP-2 in vitro, the most active being 5-amino-3-methylisoquinolin-1-one (PARP-1: IC 50 = 0.23 μM vs IC50 = 1.6 μM for 5-AIQ). Some rationalisation of the SAR was achieved through molecular modelling.

Synthesis and evaluation of estrogen agonism of diaryl 4,5- dihydroisoxazoles, 3-hydroxyketones, 3-methoxyketones, and 1,3-diketones: A compound set forming a 4D molecular library

In this paper, the preparation and systematic evaluation of estrogen receptor α (ERα) and estrogen receptor β (ERβ) activities of some diaryl-1,3-diones and their synthetic intermediates, diaryl-4,5-dihydroisoxazoles, diaryl-3-hydroxyketones, diaryl-3-met

Method for preparing chiral diphosphines

The invention concerns a method for preparing a compound of formula (1) wherein: A represents naphthyl or phenyl optionally substituted; and Ar1, Ar2independently represent a saturated or aromatic carbocyclic group, optionally substituted.

Asymmetric hydrogenation method of a ketonic compound and derivative

The present invention relates to a process for the asymmetric hydrogenation of a ketonic compound and derivative. The invention relates to the use of optically active metal complexes as catalysts for the asymmetric hydrogenation of a ketonic compound and derivative. The process for the asymmetric hydrogenation of a ketonic compound and derivative is characterized in that the asymmetric hydrogenation of said compound is carried out in the presence of an effective amount of a metal complex comprising as ligand an optically active diphosphine corresponding to one of the following formulae: STR1

3-Unsubstituted 1,5-diaryl-2,4-pentanediones and -4-methoxy-2-pentanones: Synthesis via corresponding 3-hydroxy ketones generated from 2-isoxazolines

Aryl acetaldoximes are reacted with allylarenes in the presence of sodium hypochlorite to give 3,5-bis(arylmethyl)-2-isoxazolines which are then converted to 1,5-diaryl-4-hydroxy-2-pentanones by a reductive hydrogenation in the presence of water. These in

A General Route to 3-Unsubstituted 1,5-Diaryl-2,4-pentanediones and -4-Methoxy-2-pentanones

2-Isoxazolines are converted to corresponding 3-hydroxyketones which are used as precursors to produce new 3-unsubstituted 1,5-diaryl-2,4-pentanediones and -4-methoxy-2-pentanones.

Preparation of antioxidants

This invention comprises an alkylation, reduction and transesterification process for the preparation of ester substituted phenols. The products are useful as antioxidants and may be prepared in high yields and with a high degree of purity.