51310-21-5

Basic information

• Product Name: METHYL 2-(4-OXO-3(4H)-QUINAZOLINYL)BENZOATE
• Synonyms: METHYL 2-(4-OXO-3(4H)-QUINAZOLINYL)BENZOATE;Methyl 2-(4-oxo-3,4-dihydroquinazolin-3-yl)benzoate
• CAS NO: 51310-21-5
• Molecular Formula: C₁₆H₁₂N₂O₃
• Molecular Weight: 280.28
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Quinazolines
• Mol File: 51310-21-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 461.3°Cat760mmHg
• Flash Point: 232.8°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 1.09E-08mmHg at 25°C
• Refractive Index: 1.631
• CAS DataBase Reference: METHYL 2-(4-OXO-3(4H)-QUINAZOLINYL)BENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-(4-OXO-3(4H)-QUINAZOLINYL)BENZOATE(51310-21-5)
• EPA Substance Registry System: METHYL 2-(4-OXO-3(4H)-QUINAZOLINYL)BENZOATE(51310-21-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 51310-21-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H12N2O3/c1-21-16(20)12-7-3-5-9-14(12)18-10-17-13-8-4-2-6-11(13)15(18)19/h2-10H,1H3

Upstream product

• 75541-69-4 2-(2-bromobenzoylamino)benzoic acid methyl ester 
• 77287-34-4 formamide 
• 31499-90-8 2,1-benzisoxazol-3(1H)-one 
• 122-51-0 orthoformic acid triethyl ester 
• 134-20-3 2-carbomethoxyaniline 
• 49854-16-2 methyl 2-(2-aminobenzoylamino)benzoate 

Relevant articles and documents

Synthesis of 3-substituted and 2,3-disubstituted quinazolinones via Cu-catalyzed aryl amidation

CuI/4-hydroxy-l-proline catalyzed coupling of N-substituted o-bromobenzamides with formamide takes place at 80 °C, affording 3-substituted quinazolinones directly. Under these conditions other amides that were tested only provided simple coupling products, which can be converted into 2,3-disubstituted quinazolinones via HMDS/ZnCl2 mediated condensative cyclization.