75541-69-4

Upstream product

• 7154-66-7 2-bromobenzoic acid chloride 
• 134-20-3 2-carbomethoxyaniline 
• 118-48-9 isatoic anhydride 
• 88-65-3 2-bromobenzoic-acid 

Downstream Products

• 1381841-93-5 7-phenyl-6H-isoquinolino[2,3-a]quinazoline-5,12-dione 
• 1381841-95-7 7-(4-fluorophenyl)-6H-isoquinolino[2,3-a]quinazoline-5,12-dione 
• 1381841-94-6 7-p-tolyl-6H-isoquinolino[2,3-a]quinazoline-5,12-dione 
• 950095-89-3 2-[(2-bromobenzoyl)methylamino]benzoic acid methyl ester 
• 1380084-82-1 2-(2-bromo-benzoylamino)-benzoic acid methyl ester 
• 18600-62-9 2-(2-bromobenzamido)benzoic acid 
• 1380084-71-8 2-(2-bromo-N-(carboxymethyl)benzamido)benzoic acid 
• 926268-07-7 2-[(2-bromobenzoyl)methylamino]benzoic acid 
• 51310-21-5 3-(2-carbomethoxyphenyl)-4(3H)-quinazolinone 
• 106882-27-3 2-(2-bromo-phenyl)-benzo[d][1,3]thiazin-4-one 
• 18595-86-3 2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one 
• 83389-21-3 (bromo-2 phenyl)-2 benzothiazine-3,1 thione-4 

Relevant academic research and scientific papers

Facile assembly of two 6-membered fused N-heterocyclic rings: A rapid access to novel small molecules via Cu-mediated reaction

A rapid, versatile and one-pot Cu-mediated domino reaction has been developed for facile assembly of two six membered fused N-heterocyclic rings leading to novel small molecules as potential inhibitors of PDE4. The Royal Society of Chemistry.

Palladium-catalyzed intramolecular decarboxylative coupling of arene carboxylic acids/esters with aryl bromides

Give me a ring? An efficient approach has been developed for the intramolecular decarboxylative coupling of arene carboxylic acids/esters with aryl bromides catalyzed by palladium (see scheme). From a synthetic viewpoint, this method is highly attractive because the catalyst loading is low, the optimized reaction conditions are mild, and the substrate scope is broad. Copyright

Copper-catalyzed domino synthesis of isoquinolino[2,3-a]quinazolinones

A copper-catalyzed domino method for synthesis of isoquinolino[2,3-a] quinazolinones has been developed using readily available, substituted methyl 2-(2-haloobenzamido)benzoates and nitriles as the starting materials. The domino process comprises an Ullmann-type C-arylation, intramolecular addition of NH with CN, and nucleophilic attack of amino to ester group. The inexpensive, convenient and efficient copper-catalyzed method should provide a new and useful strategy for constructing nitrogen heterocycles. Copyright

The evaluation and structure-activity relationships of 2-benzoylaminobenzoic esters and their analogues as anti-inflammatory and anti-platelet aggregation agents

Forty-seven 2-benzoylaminobenzoic esters were synthesized and evaluated in anti-platelet aggregation, inhibition of superoxide anion generation, and inhibition of neutrophil elastase release assays. Most 2-benzoylamino-4-chlorobenzoic acid derivatives showed selective inhibitory effects on arachidonic acid (AA)-induced platelet aggregation. Among them, compounds 6b and 7b exhibited more potent inhibitory effects (ca. 200-fold) than aspirin. Additionally, compounds 1a and 5a showed strong inhibitory effects on neutrophil superoxide generation with IC50 values of 0.65 and 0.17 μM, respectively. However, compounds 6d and 6e exhibited dual inhibitory effects on platelet aggregation and neutrophil elastase (NE) release; therefore, these two compounds may be new leads for development as anti-inflammatory and anti-platelet aggregatory agents.