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2'-deoxy-3'-O-methanesulfonyl-5'-O-tritylcytidine is a complex organic compound that belongs to the class of nucleoside derivatives. It is characterized by the presence of a cytidine base, which is a pyrimidine nucleobase, attached to a 2'-deoxyribose sugar. The 3'-O-methanesulfonyl group is a protecting group that masks the 3'-hydroxyl group of the sugar, preventing unwanted reactions at that site. The 5'-O-trityl group is a bulky protecting group that shields the 5'-hydroxyl group, which is crucial for protecting the molecule during synthetic processes. 2'-deoxy-3'-O-methanesulfonyl-5'-O-tritylcytidine is significant in the field of organic synthesis and medicinal chemistry, particularly in the synthesis of modified nucleosides that can be used as potential therapeutic agents or as tools in molecular biology research. The combination of these functional groups makes 2'-deoxy-3'-O-methanesulfonyl-5'-O-tritylcytidine a valuable intermediate in the development of novel nucleoside analogs with potential applications in antiviral and anticancer drug discovery.

5132-08-1

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5132-08-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5132-08-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,3 and 2 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5132-08:
(6*5)+(5*1)+(4*3)+(3*2)+(2*0)+(1*8)=61
61 % 10 = 1
So 5132-08-1 is a valid CAS Registry Number.

5132-08-1Relevant academic research and scientific papers

Synthesis and antileukemic activity of chymotrygsin-activated derivatives of 3'-amino-2',3'-dideoxycytidine. (Synthetic nucleosides and nucleotides. XXXIII

Kawaguchi,Sakairi,Kimura,Yamaguchi,Saneyoshi

, p. 501 - 504 (1995)

3'-Amino-2',3'-dideoxycytidine (8) was directly synthesized from 2'-deoxycytidine, 2',3'-Dideoxy-3'-(N-acyl-L-phenylalanylamino)cytidines (acyl =butoxycarbonyl (9a), acetyl (9b), benzoyl (9c), and α-hexanoyl (9d)) were synthesized as chymotrypsin-activated prodrugs of 8. This N-protection was required for activation by chymotrypsin to 8. In vitro, compound 8 showed high cytotoxic activity against P388 cells, but the prodrugs 9a-d were ineffective. In vitro, however, these prodrugs showed much higher activity than 8 in mice bearing P388 cells.

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