Chemical and Pharmaceutical Bulletin p. 501 - 504 (1995)
Update date:2022-08-04
Topics:
Kawaguchi
Sakairi
Kimura
Yamaguchi
Saneyoshi
3'-Amino-2',3'-dideoxycytidine (8) was directly synthesized from 2'-deoxycytidine, 2',3'-Dideoxy-3'-(N-acyl-L-phenylalanylamino)cytidines (acyl =butoxycarbonyl (9a), acetyl (9b), benzoyl (9c), and α-hexanoyl (9d)) were synthesized as chymotrypsin-activated prodrugs of 8. This N-protection was required for activation by chymotrypsin to 8. In vitro, compound 8 showed high cytotoxic activity against P388 cells, but the prodrugs 9a-d were ineffective. In vitro, however, these prodrugs showed much higher activity than 8 in mice bearing P388 cells.
View MoreHangzhou Think Chemical Co. Ltd
website:http://www.thinkchem.com/
Contact:86-571-89986307/81956191/81956084/81956192
Address:Room 501-502, Tower E, Yuanjian Building, Yuanyang International Center, Hangzhou-310011, China
Shanghai Xinda Pharmaceuticals Co., Ltd.
Contact:86-21-33692333-8008
Address:999 Linxian Road, Jinshan Industrial Park, Shanghai, China
Jiangsu Institute of Ecomones Co., Ltd
website:http://www.jsmone.com
Contact:+86-519-82821700
Address:95 Huanyuan N. Road, Jintan, Jiangsu, China
Shanghai Demand Chemical Co., ltd,China
Contact:86-021-55237578/55239122
Address:Room 3H, No.578, Yingkou Road, Yangpu District, Shanghai, China
AstaTech ( Chengdu) BioPharmaceutical Corp.
website:http://www.astabiochem.cn/
Contact:+86-15198215156-15198215156
Address:SICHUAN CHENGDU
Doi:10.1021/ja01291a040
(1937)Doi:10.1002/ejoc.201901752
(2020)Doi:10.1016/0008-6215(83)88140-3
(1983)Doi:10.1039/c6ra16118a
(2016)Doi:10.1081/CAR-120016846
(2002)Doi:10.1021/jm0309046
(2003)