51324-23-3

Upstream product

• 2227-79-4 benzenecarbothioamide 
• 51324-24-4 2-bromo-1,2-bis-(p-chlorophenyl)-ethanone 
• 106-39-8 bromochlorobenzene 
• 600732-11-4 2-phenyl-1,3-thiazole-5-carboxanilide 
• 53715-67-6 5-bromo-2-phenyl-1,3-thiazole 
• 637-87-6 1-Chloro-4-iodobenzene 
• 122395-24-8 4-(4′-chlorophenyl)-2-phenylthiazole 

Relevant academic research and scientific papers

Direct arylation of thiazoles on water

Wetter is better: The direct arylation of thiazoles on water is quicker, cleaner, and higher-yielding than arylation in organic solvents. The reaction works under mild conditions for an array of aryl iodides, producing 2,5-diaryl thiazoles in excellent yields. Importantly, novel bi-heteroaryl compounds are produced without the requirement for stoichiometric organometallic coupling agents. (Figure Presented).

Palladium-catalyzed direct arylation of thiazoles with aryl bromides

Thiazole, 2-phenyl or -alkyl substituted one and benzothiazole are efficiently arylated with aryl bromides at the 2- and/or 5-position(s) in the presence of Pd(OAc)2 and a bulky phosphine ligand using Cs2CO3 as base. 2-Phenyl-5-thiazolecarboxanilide undergoes successive diarylation at the 4- and 5-positions accompanied by decarbamoylation.