51334-85-1Relevant articles and documents
Palladium-Catalyzed Acylation Reactions: A One-Pot Diversified Synthesis of Phthalazines, Phthalazinones and Benzoxazinones
Suchand, Basuli,Satyanarayana, Gedu
, p. 2233 - 2246 (2018/06/04)
A sequential one-pot strategy for the diversified synthesis of phthalazines, phthalazinones and benzoxazinones was presented. This strategy proceeds through [Pd]-catalyzed acylation and nucleophilic cyclocondensation with dinucleophilic reagents. This process was based on direct coupling with simple bench-top aldehydes without the assistance of directing group and without activating the carbonyl group. The process is highly advantageous because it employs simple nitrogen-based nucleophiles, and non-toxic and readily accessible aldehydes as the carbonyl source. Most importantly, the strategy was applied to the one-pot synthesis of PDE-4 inhibitor.
Synthesis, Antiviral, and Antimicrobial Activity of N- and S-Alkylated Phthalazine Derivatives
Moustafa, Ahmed H.,El-Sayed, Hassan A.,Abd El-Hady, Rasha A.,Haikal, Abdelfattah Z.,El-Hashash, Maher
, p. 789 - 799 (2016/05/19)
A series of N-alkylphthalazinone were synthesized by the reaction of phthalazin-1(2H)-one derivatives 1a, 1b, 1c with alkylating agents namely, propargyl, allyl bromide, epichlorohydrin, 1,3-dichloro-2-propanol, 4-bromobutylacetate, and 1-(bromomethoxy)et
Chemoselectivity of 2-arylmethyleneaminoisoindolin-1,3-diones toward arenes under friedel-crafts conditions: An efficient synthesis of benzophenones integrated with 2-substituted hydrazone moieties
Derbala, Hamed A.
experimental part, p. 700 - 704 (2012/08/27)
Treatment 2-arylmethyleneaminoisoindole-1,3-diones 1a-c with arenes in the presence of AlCl3-DMF complex as a catalyst afforded the novel compounds, 2-((arylidenehydrazono)(aryl)-methyl)benzophenones 3a-n in satisfactory yields. The structure of the obtained products 3a-n was confirmed by the use of IR, 1H-NMR, 13C-NMR, mass spectra, and elemental analyses.
