51362-40-4

Usage

Uses

Used in Pharmaceutical Research and Development:
6-Phenoxy-pyridine-2-carboxylic acid is utilized as a key intermediate in the synthesis of potential drug candidates due to its unique chemical structure and properties. Its ability to form hydrogen bonds and chelate metal ions makes it a valuable component in the development of new therapeutic agents.
Used in Antiviral and Antimicrobial Applications:
6-Phenoxy-pyridine-2-carboxylic acid is studied for its potential biological activities, particularly as an antiviral and antimicrobial agent. Its heterocyclic structure and functional groups may contribute to its ability to inhibit the replication and growth of viruses and bacteria, offering a promising avenue for the development of new antimicrobial drugs.
Used as a Chelating Agent for Metal Ions:
6-Phenoxy-pyridine-2-carboxylic acid is recognized for its chelating properties, making it useful as a chelating agent for metal ions. This application is significant in various industries, including environmental remediation, where it can help in the sequestration and removal of toxic metal ions from contaminated sites.
Used in Materials Science:
In the field of materials science, 6-phenoxy-pyridine-2-carboxylic acid may find applications in the development of new materials with specific properties, such as conductivity, magnetism, or catalytic activity. Its aromatic and heterocyclic nature allows for the formation of complexes and coordination compounds with various metal ions, expanding its potential uses in material design.
Used in Organic Synthesis:
6-Phenoxy-pyridine-2-carboxylic acid serves as a versatile building block in organic synthesis, enabling the creation of a wide range of organic compounds with diverse applications. Its reactivity and functional groups make it a valuable precursor for the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.

Upstream product

• 626-05-1 2,6-Dibromopyridine 
• 83247-00-1 2-bromo-6-phenoxypyridine 
• 124-38-9 carbon dioxide 
• 108-95-2 phenol 

Downstream Products

• 83282-58-0 N-(5-tetrazolyl)-6-phenoxy-2-pyridinecarboxamide 

Relevant academic research and scientific papers

AMIDE COMPOUND AND PHARMACEUTICAL COMPRISING SAME

Provided is a novel compound which has an excellent Aβ aggregation inhibitory effect and is useful as a pharmaceutical. An amide compound represented by the formula (1) or a salt thereof, wherein Z represents CH or N; A and B are the same or different and each represents —CH2—, —O—, —S—, or —NH—; R1 and R2 are the same or different and each represents a branched alkyl group, a branched alkenyl group, an optionally substituted aromatic hydrocarbon group, an optionally substituted aralkyl group, an optionally substituted cycloalkyl group, or an optionally substituted aromatic heterocyclic group; and R3 represents a branched alkyl group, a branched alkenyl group, an optionally substituted cycloalkyl group, or an optionally substituted aralkyl group.

Rational design and identification of a non-peptidic aggregation inhibitor of amyloid-β based on a pharmacophore motif obtained from cyclo[-Lys-Leu-Val-Phe-Phe-]

Inhibition of pathogenic protein aggregation may be an important and straightforward therapeutic strategy for curing amyloid diseases. Small-molecule aggregation inhibitors of Alzheimer's amyloid-β (Aβ) are extremely scarce, however, and are mainly restricted to dye- and polyphenol-type compounds that lack drug-likeness. Based on the structure-activity relationship of cyclic Aβ16-20 (cyclo-[KLVFF]), we identified unique pharmacophore motifs comprising side-chains of Leu2, Val3, Phe4, and Phe5 residues without involvement of the backbone amide bonds to inhibit Aβ aggregation. This finding allowed us to design non-peptidic, small-molecule aggregation inhibitors that possess potent activity. These molecules are the first successful non-peptidic, small-molecule aggregation inhibitors of amyloids based on rational molecular design.

Herbicidal carboxamide derivatives

The invention provides compounds of the general formula in whichR1 represents a hydrogen or halogen atom or an alkyl or haloalkyl group;the or each group X independently represents a halogen atom or an optionally substituted alkyl or alkoxy group or an alkenyloxy, alkynyloxy, cyano, carboxy, alkoxycarbonyl, (alkylthio)carbonyl, alkylcarbonyl, amido, alkylamido, nitro, alkylthio, haloalkylthio, alkenylthio, alkynylthio, alkylsulphinyl, alkylsulphonyl, alkyloximinoalkyl or alkenyloximinoalkyl group;n is 0 or an integer from 1 to 5; andL is an alkoxy group.