51362-49-3

Basic information

• Product Name: 2-PHENOXYPYRIDINE-3-CARBONYL CHLORIDE
• Synonyms: 2-PHENOXYPYRIDINE-3-CARBONYL CHLORIDE;BUTTPARK 43\57-06;2-Phenoxypyridine-3-carbonyl chloride, tech;2-PHENOXYPYRIDINE-3-CARBONYLHLORIDE, 95+%;2-Phenoxypyridine-3-carbonylhloride;3-(Chlorocarbonyl)-2-phenoxypyridine, 3-(Chlorocarbonyl)pyridin-2-yl phenyl ether;2-Phenoxynicotinoyl chloride
• CAS NO: 51362-49-3
• Molecular Formula: C₁₂H₈ClNO₂
• Molecular Weight: 233.65
• Mol File: 51362-49-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 90 °C
• Boiling Point: 341.1 °C at 760 mmHg
• Flash Point: 160.1 °C
• Appearance: /
• Density: 1.3 g/cm³
• Vapor Pressure: 8.25E-05mmHg at 25°C
• Refractive Index: 1.594
• PKA: -0.06±0.22(Predicted)
• CAS DataBase Reference: 2-PHENOXYPYRIDINE-3-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENOXYPYRIDINE-3-CARBONYL CHLORIDE(51362-49-3)
• EPA Substance Registry System: 2-PHENOXYPYRIDINE-3-CARBONYL CHLORIDE(51362-49-3)

Safety Data

• Hazard Codes: Xi
• Statements: 34-43
• Safety Statements: 26-36/37/39-45-36/37
• RIDADR: 3261
• Hazardous Substances Data: 51362-49-3(Hazardous Substances Data)

Usage

General Description

2-Phenoxy Pyridine-3-Carbonyl Chloride is a chemical compound with the molecular formula C12H8ClNO2. It is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. 2-PHENOXYPYRIDINE-3-CARBONYL CHLORIDE is a reactive acyl chloride that is often used as an intermediate in the production of medicines and pesticides. It is known for its ability to undergo various chemical reactions, including coupling reactions, nucleophilic substitution, and amide formation. Additionally, it is also used as a reagent in organic synthesis and as a building block in the development of other complex molecules. Overall, 2-Phenoxy Pyridine-3-Carbonyl Chloride is a versatile and important chemical compound with various applications in the pharmaceutical and agrochemical industries.

InChI:InChI=1/C12H8ClNO2/c13-11(15)10-7-4-8-14-12(10)16-9-5-2-1-3-6-9/h1-8H

Upstream product

• 108-95-2 phenol 
• 2942-59-8 2-chloronicotinic acid 
• 553-53-7 Nicotinic acid hydrazide 
• 936-02-7 2-Hydroxybenzoylhydrazine 

Downstream Products

• 240418-29-5 N-{2-hydroxy-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propyl}-2-phenoxy-nicotinamide 
• 643746-76-3 tert-butyl 4-(3-{[(2-phenoxy-3-pyridinyl)carbonyl]amino}phenyl)-1-piperidinecarboxylate 
• 218157-36-9 N'-(2-phenoxypyridine-3-carbonyl)-3-(trifluoromethyl)benzhydrazide 
• 917913-89-4 3-(3-bromobenzyl)-8-(2-phenoxypyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one 
• 892390-64-6 tert-butyl (3S)-3-{isobutyl[(2-phenoxypyridin-3-yl)carbonyl]amino}pyrrolidine-1-carboxylate 

Relevant articles and documents

Design, Synthesis, and Herbicidal Activity of Novel Diphenyl Ether Derivatives Containing Fast Degrading Tetrahydrophthalimide

To seek new protoporphyrinogen oxidase (PPO) inhibitors with better biological activity, a series of novel diphenyl ether derivatives containing tetrahydrophthalimide were designed based on the principle of substructure splicing and bioisomerization. PPO inhibition experiments exhibited that 6c is the most potential compound, with the half-maximal inhibitory concentration (IC50) value of 0.00667 mg/L, showing 7 times higher activity than Oxyfluorfen (IC50 = 0.0426 mg/L) against maize PPO and similar herbicidal activities to Oxyfluorfen in weeding experiments in greenhouses and field weeding experiments. In view of the inspected bioactivities, the structure-activity relationship (SAR) of this series of compounds was also discussed. Crop selection experiments demonstrate that compound 6c is safe for soybeans, maize, rice, peanuts, and cotton at a dose of 300 g ai/ha. Accumulation analysis experiments showed that the accumulation of 6c in some crops (soybeans, peanuts, and cotton) was significantly lower than Oxyfluorfen. Current work suggests that compound 6c may be developed as a new herbicide candidate in fields.

Substituted N'-(arylcarbonyl)-benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae I and II: wherein Ar1, Ar2, and R1-R2 are defined herein. The present invention also relates to the discovery that compounds having Formulae I and II are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.