51381-78-3

Basic information

• Product Name: 6-methyl-8-nitrophenanthridine
• CAS NO: 51381-78-3
• Molecular Formula: C₁₄H₁₀N₂O₂
• Molecular Weight: 238.2414
• Mol File: 51381-78-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 436°C at 760 mmHg
• Flash Point: 217.5°C
• Density: 1.33g/cm³
• Vapor Pressure: 2.13E-07mmHg at 25°C
• Refractive Index: 1.729
• CAS DataBase Reference: 6-methyl-8-nitrophenanthridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-8-nitrophenanthridine(51381-78-3)
• EPA Substance Registry System: 6-methyl-8-nitrophenanthridine(51381-78-3)

Safety Data

• Hazardous Substances Data: 51381-78-3(Hazardous Substances Data)

Upstream product

• 84-66-2 Diethyl phthalate 
• 108753-63-5 11-methyl-2-nitro-dibenzo[b,f][1,4]thiazepine 
• 108849-67-8 1-[2-(2-amino-phenylsulfanyl)-5-nitro-phenyl]-ethanone 
• 1233011-72-7 1-(4'-nitrobiphenyl-2-yl)ethanone 
• 24067-17-2 4-nitrophenylboronic acid 
• 2142-69-0 2-bromophenyl methyl ketone 
• 65130-31-6 1-(2′-bromo-5′-nitrophenyl)ethan-1-one 
• 71857-97-1 2-acetamino-4'-nitro-1,1'-biphenyl 

Downstream Products

• 78255-99-9 8-nitro-phenanthridin-6-ol 

Relevant articles and documents

Preparation of 6-substituted phenanthridines from o-biaryl ketoximes via the Beckmann rearrangement

Treatment of anti alkyl o-biaryl ketoximes and anti aryl o-biaryl ketoximes with Tf2O at 120 °C, followed by quenching with Et3N gave 6-alkylphenanthridines and 6-arylphenanthridines in good yields, respectively. These reactions proceeded through the O-triflation of the ketoximes, the Beckmann rearrangement, and the electrophilic cyclization of the formed nitrilium group onto the aromatic ring.