51417-62-0

Upstream product

• 186581-53-3 diazomethane 
• 53243-89-3 E,E-2,3-dibenzylidene succinic acid 
• 67-56-1 methanol 
• 51417-60-8 α-bromo-trans-cinnamic acid-anhydride 
• 201230-82-2 carbon monoxide 
• 886-66-8 1,4-diphenyl-1,3-butadiyne 
• 53244-03-4 Lithium; (E)-2-bromo-3-phenyl-acrylate 

Downstream Products

• 53243-96-2 (E,E)-2,3-Bis-1,4-diphenylbutadiene 
• 18654-24-5 dimethyl (3E)-2-benzyl-3-benzylidenesuccinate 
• 54375-35-8 2,5-Dimethyl-3,4-bis-[1-phenyl-meth-(E)-ylidene]-hexane-2,5-diol 
• 1129282-90-1 (+/-)-benzyl-((E)-benzylidene)-succinic acid 
• 65756-86-7 2,3-dibenzyl-succinic acid dimethyl ester 

Relevant academic research and scientific papers

Stereoselective Synthesis of Highly Substituted Conjugated Dienes via Pd-Catalyzed Carbonylation of 1,3-Diynes

The stereoselective synthesis of conjugated dienes was realized for the first time via Pd-catalyzed alkoxycarbonylation of easily available 1,3-diynes. Key to success is the utilization of the specific ligand 1,1′-ferrocenediyl-bis(tert-butyl(pyridin-2-yl)phosphine) (L1), which allows this novel transformation to proceed at room temperature. A range of 1,2,3,4-tetrasubstituted conjugated dienes are obtained in this straightforward access in high yields and selectivities. The synthetic utility of the protocol is showcased in the concise synthesis of several important intermediates for construction of natural products rac-cagayanin, rac-galbulin, rac-agastinol, and cannabisin G.