51432-61-2Relevant academic research and scientific papers
A novel method for preparation of optically active α-monobenzoyl glycerol via lipase-catalyzed asymmetric transesterification of glycerol
Kato, Yasuo,Fujiwara, Isao,Asano, Yasuhisa
, p. 3207 - 3210 (1999)
One-step synthesis of optically active α-monobenzoyl glycerol is described by lipase-catalyzed transesterification of benzoate derivatives with glycerol in 1,4-dioxane.
Macrocyclic MCL-1 inhibitors and methods of use
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Paragraph 0767, (2019/02/28)
The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
Synthesis of enantiomerically pure (R)-and (S)-1-benzoyloxypropane-2,3-diol and revision of the stereochemical outcome of the Candida antarctica lipase-catalyzed benzoylation of glycerol
Casati, Silvana,Ciuffreda, Pierangela,Santaniello, Enzo
experimental part, p. 658 - 661 (2011/07/08)
Enantiomerically pure (R)- and (S)-1-benzoyloxypropane-2,3-diol have been prepared from (S)-(+)-2,2-dimethyl-1,3-dioxolane-4-methanol and used as reference compounds to correct the reported stereochemical outcome of the Candida antarctica lipase (CAL)-cat
Strategy for specific isotope ratio determination by quantitative NMR on symmetrical molecules: application to glycerol
Caytan, Elsa,Cherghaoui, Younes,Barril, Celia,Jouitteau, Catherine,Rabiller, Claude,Remaud, Gerald S.
, p. 1622 - 1624 (2007/10/03)
The strategy for the measurement of the site-specific isotope ratios by NMR within a symmetrical molecule is illustrated by the determination of the site-specific 13C content in glycerol on the basis of (i) a selective derivatisation of glycerol, carried out by a lipase (Candida antarctica) to overcome the symmetry of the molecule, (ii) purification of the (R)-monobenzoate glycerol with a high enantiomeric excess and (iii) use of this derivative for quantitative 13C NMR spectroscopy for the determination of 13C isotopomer concentrations.
Microbial asymmetric reduction of α-hydroxyketones in the anti-Prelog selectivity
Tsujigami, Toshikuni,Sugai, Takeshi,Ohta, Hiromichi
, p. 2543 - 2549 (2007/10/03)
Yamadazyma farinosa IFO 10896 was found to reduce α-hydroxyketones bearing a phenyl ring to give optically active diols with anti-Prelog selectivity. The distance between the carbonyl group and the phenyl ring was shown to have an interesting effect on the reactivity and selectivity of the enzyme system.
Optical Resolution and Chiral Synthesis of Methyl 6,7-Dichloro-2,3-dihydrobenzofuran-2-carboxylate
Yodo, Mitsuaki,Matsushita, Yoshihiro,Ohsugi, Eiichi,Harada, Hiroshi
, p. 902 - 913 (2007/10/02)
Optical isomers of methyl 6,7-dichloro-2,3-dibenzofuran-2-carboxylate (2) were prepared by means of both optical resolution and chiral synthesis.The resolution of the carboxylic acid 3 was achieved in a practical and efficient way via the l- and d-menthyl esters, which were directly converted to enantiomers of 2.Chiral synthesis of 2 was attained with high optical yield via acid-catalyzed cyclization of the β-hydroxysulfide 10 derived from optically active glycidyl phenyl sulfide 13.The optical resolution method was considered to be better for large-scale preparation from the economical and operational viewpoints.Keywords - methyl 6,7-dichloro-2,3-dibenzofuran-2-carboxylate; optical resolution; (R)-4-phenyl-2-oxazolidone; menthol; chiral synthesis; glycidyl phenyl sulfide; β-hydroxysulfide; episulfonium ion; S-8666
Enzymatic Differentiation of the Enantiotopic Hydroxymethyl Groups of Glycerol; Synthesis of Chiral Building Blocks
Breitgoff, Detlev,Laumen, Kurt,Schneider, Manfred P.
, p. 1523 - 1524 (2007/10/02)
The prochiral (3b), derived from glycerol, was transformed by enantioselective, enzymatic hydrolysis into the central chiral building block (R)-(4) of high enantiometric purity, which was further elaborated into a variety of chiral building blocks with th
