51440-79-0Relevant academic research and scientific papers
Access to amphiphilic cis-configurated polyamide-3 using alcohols as initiators
Maiatska, Olga,Belkin, Alexander,Ritter, Helmut
, p. 2367 - 2369 (2015/05/13)
The synthesis of polyamide-3 from 4a,5,8,8a-tetrahydro-1H-benzo[d][1,3]oxazine-2,4-dione (β-NCA, 1) using methanol, dye (Disperse Red 13), and poly(ethylene glycol) as initiator is described. The ring-opening polymerization under release of CO2 produces polyamides-3 with definite terminal groups, high purity, and relatively narrow dispersity. This route was used for preparation of block copolymers from as an example.
Synthesis of N-heterocyclic compounds via ene-yne metathesis reactions
Groaz, Elisabetta,Banti, Donatella,North, Michael
, p. 204 - 218 (2008/03/28)
Propargylamino and allylamino derivatives of cyclohexene and norbornene were subjected to tandem metathesis reactions with first and second generation Grubbs' catalysts 1 and 2. Results show that the method is compatible with suitably protected nitrogen-containing compounds. Cyclohexenes gave intriguing results in terms of the possibility to perform ring rearrangement metathesis (RRM) reactions, showing a difference with the analogous allyl and propargyl ether substrates.
2-Methyl-4,5-dihydroimidazole as a Doubly Nucleophilic Unit: Preparation of Dihydroimidazole Azaprostanoids
Jones, Raymond C. F.,Schofield, Julie
, p. 375 - 383 (2007/10/02)
2-Methyl-4,5-dihydroimidazole is incorporated as a doubly nucleophilic synthon, by successive alkylations at N-1 and C-2(Me), into monocyclic 9,12- and 8,11-diazaprostanoids containing the dihydroimidazole moiety. 2-Methyl-3a,4,7,7a-tetrahydrobenzimidazole is prepared (from 1,2,3,6-tetrahydrophthalic anhydride) and elaborated in the same way into a diazaprostacyclin precursor.
EXPERIMENTAL STUDIES OF THE ANOMERIC EFFECT. PART 2 RING INVERSION AND NITROGEN INVERSION EQUILIBRIA IN CIS-DECAHYDROQUINAZOLINES
Booth, Harold,Khedhair, Khedhair A.,Al-Shirayda, Hatif A. R. Y.
, p. 1465 - 1476 (2007/10/02)
The positions of conformational equilibria due to the double ring inversion in cis-decahydroquinazoline (7-->//07-->8 1.08 kcal mol-1; -ΔG09-->10 1.10 kcal mol-1) for the conformation which would allow the lone pairs on N(1) and N(3) to lie on the hindered 'inside' face of the molecules.However, the values of 3J(CHNH) coupling constants for both cis-decahydro-3-methylquinazoline (10) and cis (4aH, 8aH) cis (2H, 8aH)-decahydro-2,3-dimethylquinazoline (14) show that the N-inversion equilibrium at N(1) prefers the conformation in which N(1)-H is 'inside' (axial), and N(1)-lone pair equatorial, thus demonstrating the ability of the anomeric effect to outweigh steric repulsions.
Stereocontrolled Syntheses for the Six Diastereomeric 1,2-Dihydroxy-4,5-diaminocyclohexanes: PtII Complexes and P-388 Antitumor Properties
Witiak, Donald T.,Rotella, David P.,Filppi, Joyce A.,Gallucci, Judith
, p. 1327 - 1336 (2007/10/02)
Stereocontrolled syntheses for the six diastereomeric 1,2-dihydroxy-4,5-diaminocyclohexanes 3a-f from cyclohexene diamines cis-4 and trans-5 are described.Cbz-protected species cis-9 and trans-11, respectively, served as a source of stable Cbz-protected p
