51449-77-5

Basic information

• Product Name: 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE
• Synonyms: 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE;2-(1H-Tetrazol-5-yl)phenol, 97%;5-(o-Hydroxyphenyl)tetrazole
• CAS NO: 51449-77-5
• Molecular Formula: C₇H₆N₄O
• Molecular Weight: 162.14874
• Mol File: 51449-77-5.mol
• Article Data: 74

Chemical Properties

• Melting Point: 230°C
• Boiling Point: 391.8 °C at 760 mmHg
• Flash Point: 190.8 °C
• Appearance: /
• Density: 1.458 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.668
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.02±0.10(Predicted)
• CAS DataBase Reference: 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE(51449-77-5)
• EPA Substance Registry System: 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE(51449-77-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 51449-77-5(Hazardous Substances Data)

Usage

General Description

5-(2-HYDROXYPHENYL)-1H-TETRAZOLE is a chemical compound with the molecular formula C7H6N4O. It is a type of tetrazole derivative that contains a hydroxyphenyl group. 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE is commonly utilized in organic chemistry and pharmaceutical research, particularly for its potential as a ligand in metal coordination chemistry and as a building block for drug design. It has also been studied for its potential biological activities, including anti-inflammatory and anti-cancer properties. Additionally, 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE may also have potential applications in material science and as a component in the synthesis of complex organic molecules.

InChI:InChI=1/C7H6N4O/c12-6-4-2-1-3-5(6)7-8-10-11-9-7/h1-4,12H,(H,8,9,10,11)

Upstream product

• 611-20-1 salicylonitrile 
• 96-10-6 diethyl aluminiumcholoride 
• 94-67-7 salicylaldehyde-oxime 
• 90-02-8 salicylaldehyde 
• 95-56-7 2-hydroxybromobenzene 
• 533-58-4 2-Iodophenol 
• 29577-53-5 2-Methoxy-benzaldehyde oxime 
• 68314-54-5 1-bromo-2-(methoxymethoxy)benzene 

Downstream Products

• 76310-72-0 <(4-hydroxy-3-1H-tetrazol-5-yl)phenyl>ethanone 
• 611-20-1 salicylonitrile 
• 539-80-0 Tropone 
• 95-48-7 ortho-cresol 
• 76310-71-9 2-bromo-1-<4-hydroxy-3-(1H-tetrazol-5-yl)phenyl>ethanone 
• 473731-78-1 C₇H₅N₅O₃ 
• 172352-72-6 tetrazolylphenyl pivalate 

Relevant articles and documents

Synthesis and characterization of magnetic Fe3O4@Creatinine@Zr nanoparticles as novel catalyst for the synthesis of 5-substituted 1H-tetrazoles in water and the selective oxidation of sulfides with classical and ultrasonic methods

Tetrazoles and sulfoxide compounds have a wide range of applications in industries and are of great expectation to be environmentally friendly and cost-effective. This paper reports the introduction of zirconium supported on Fe3O4 na

Fe3O4@L-lysine-Pd(0) organic–inorganic hybrid: As a novel heterogeneous magnetic nanocatalyst for chemo and homoselective [2 + 3] cycloaddition synthesis of 5-substituted 1H-tetrazoles

An efficient and sustainable synthetic protocol has been presented to synthesis and 5-substituted 1H-tetrazole privileged heterocyclic substructures. The synthetic protocol involves two-component reaction between aryl nitriles and NaN3 in water using complex of L-lysine-palladium nanoparticles (NPs) modified Fe3O4 nanoparticles as magnetically separable, recyclable, and reusable heterogeneous catalyst. Magnetically retrievable L-lysine-Pd(0) modified Fe3O4 nanoparticles were applied in [2 + 3] cycloaddition synthesis of 5-substituted 1H-tetrazoles. The advantages of this strategy include easy recovery and efficient reusability of the expensive Pd NPs, obtaining high yields of [2 + 3] cycloaddition, short reaction times, and all of the reported synthetic strategies are being performed in water as green solvent for a wide range of substrates.

Synthesis and Characterization of Magnetic Functionalized Ni and Cu Nano Catalysts and Their Application in Oxidation, Oxidative Coupling and Various Multi-Component Reactions

Abstract: Two magnetic nano catalysts of nickel and copper, Fe3O4@SiO2@DOP-BenPyr-M(II), (M=Ni and Cu) have been synthesized. These catalysts were applied as recoverable, efficient and new heterogeneous catalysts for the high yielding and room temperature one-pot procedure of selective oxidation of sulfides to sulfoxides and oxidative coupling of thiols to disulfides. In addition, the catalytic activity of Fe3O4@SiO2@DOP-BenPyr-Ni(II) was investigated as heterogeneous nanocatalyst for synthesis of 2,3-dihydroquinazolin-4(1H)-ones, 5-substituted 1H-tetrazoles and polyhydroquinolines. The synthesized catalysts were characterized by FT-IR, TGA, XRD, VSM, EDX, ICP and SEM techniques. These catalysts were recovered by an external magnet and reused several times without significant loss of catalytic efficiency. Graphic Abstract: [Figure not available: see fulltext.]