514805-98-2

Upstream product

• 328286-61-9 4-(2-benzhydryloxy-ethyl)-1-(4-fluoro-benzyl)-1,2,3,6-tetrahydro-pyridine 
• 328286-59-5 2-[1-(4-fluorobenzyl)-1,2,3,6-tetrahydropyridin-4-yl]ethanol 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 5344-27-4 4-(2-hydroxyethyl)pyridine 

Downstream Products

• 960071-49-2 racemic 3-keto-4-[2-(diphenylmethoxy)ethyl]-1-[(4-fluorophenyl)methyl]piperidine oxalate salt 
• 960071-42-5 (1S)-4,7,7-trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (R,R)-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-yl ester 
• 514805-93-7 (1S)-4,7,7-trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (S,S)-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-yl ester 

Relevant academic research and scientific papers

High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: Stereospecific interactions in vitro and in vivo

In our effort to develop high-affinity ligands for the dopamine transporter which might find potential use as cocaine medication, a polar hydroxy substituent was introduced into the piperidine ring of one of our disubstituted lead analogues derived from 1

N-and o-substituted 4-[2-( diphenylmethoxy) -ethyl]-1- (phenyl) methyl) piperidine analogs and methods of treating cns disorders therewith

N- and O-substituted 4[2-diaromaticmethoxy and methylamino)alkyl]piperidines exhibit high CNS activity with respect to the dopamine transporter (DAT) and serotonin transporter (SERT). Preferred compounds exhibit highly differential behavior as between the