51496-25-4Relevant academic research and scientific papers
Allylphenols as a new class of human 15-lipoxygenase-1 inhibitors
Alavi, Seyed Jamal,Seyedi, Seyed Mohammad,Saberi, Satar,Safdari, Hadi,Eshghi, Hossein,Sadeghian, Hamid
, p. 259 - 266 (2020/10/12)
In this study, a series of mono- and diallylphenol derivative were designed, synthesized, and evaluated as potential human 15-lipoxygenase-1 (15-hLOX-1) inhibitors. Radical scavenging potency of the synthetic allylphenol derivatives was assessed and the results were in accordance with lipoxygenase (LOX) inhibition potency. It was found that the electronic natures of allyl moiety and para substituents play the main role in radical scavenging activity and subsequently LOX inhibition potency of the synthetic inhibitors. Among the synthetic compounds, 2,6-diallyl-4-(hexyloxy)phenol (42) and 2,6-diallyl-4-aminophenol (47) showed the best results for LOX inhibition (IC50 = 0.88 and 0.80 μM, respectively).
": A Jack of Trio "-robust one-pot metal free oxidative amination, azidation and peroxidation of phenols
Sarkar, Debayan,Ghosh, Manoj Kumar,Rout, Nilendri,Kuila, Puspendu
, p. 3715 - 3718 (2017/07/12)
Herein we disclose a highly efficient methodology for the generation of nitrogen containing quaternary carbon centres via aminative and azidative oxidative dearomatization of phenols. The same protocol has also been successfully employed to achieve oxidative peroxidation of phenols. The simplest metal free reaction conditions delineate an easy breakthrough to the "Trio"- oxidative amination, azidation and peroxidation. An array of diverse polyfunctionalised heterocycles has been synthesized in one pot.
A new one-pot synthetic approach to the highly functionalized (Z)-2-(buta-1,3-dienyl)phenols and 2-methyl-2H-chromenes: Use of amine, ruthenium and base-catalysis
Ramachary, Dhevalapally B.,Narayana, Vidadala V.,Ramakumar, Kinthada
supporting information; experimental part, p. 3907 - 3911 (2009/04/07)
A practical and simple one-pot multi-catalysis process for the synthesis of highly substituted benzo[b]oxepines 5, (Z)-2-(buta-1,3-dienyl)phenols 6 and 2-methyl-2H-chromenes 7 from simple starting materials was achieved for the first time through ring-closing metathesis/base-induced ring opening/[1,7]-sigmatropic hydrogen shift reactions. The synthesis of privileged (Z)-2-(buta-1,3-dienyl)phenols 6 via base-induced ring opening of highly functionalized benzo[b]oxepines 5 is described. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
A new synthesis of substituted 2,5-dihydro[b]-oxepines
Wang, Eng-Chi,Hsu, Ming-Kun,Lin, Yu-Li,Huang, Keng-Shiang
, p. 1997 - 2010 (2007/10/03)
Based on Claisen rearrangement, Baeyer-Villiger oxidation, and ring-closing metathesis (RCM), a series of substituted 2,5-dihydrobenzo[b]-oxepines were synthesized from isovanillin in good over-all yields. Other appropriate substituted 2,5-dihydrobenzo[b]oxepines prepared from corresponding phenol derivatives were also described.
