26509-47-7

Upstream product

• 23431-48-3 allyl p-tolyl ether 
• 1121-70-6 sodium 4-methylphenoxide 
• 106-95-6 allyl bromide 
• 71-43-2 benzene 
• 106-44-5 p-cresol 
• 107-05-1 3-chloroprop-1-ene 
• 6628-06-4 2-allyl-4-methylphenol 
• 51496-25-4 3-allyl-4-allyloxytoluene 

Downstream Products

• 26509-49-9 4-methyl-2,6-dibutyrylphenol 
• 5397-51-3 allyl-(4-methyl-2,6-dipropyl-phenyl)-ether 
• 1260370-62-4 (Ce(2,6-diallyl-4-methylphenolato)2(μ-2,6-diallyl-4-methylphenolato))2 
• 1260370-66-8 (Y(2,6-diallyl-4-methylphenolato)2(μ-2,6-diallyl-4-methylphenolato))2 
• 1260370-64-6 (Er(2,6-diallyl-4-methylphenolato)2(μ-2,6-diallyl-4-methylphenolato))2 
• 1260370-65-7 (Yb(2,6-diallyl-4-methylphenolato)2(μ-2,6-diallyl-4-methylphenolato))2 
• 1260370-61-3 (La(2,6-diallyl-4-methylphenolato)2(μ-2,6-diallyl-4-methylphenolato))2 
• 1260370-63-5 (Nd(2,6-diallyl-4-methylphenolato)2(μ-2,6-diallyl-4-methylphenolato))2 

Relevant academic research and scientific papers

Allylphenols as a new class of human 15-lipoxygenase-1 inhibitors

In this study, a series of mono- and diallylphenol derivative were designed, synthesized, and evaluated as potential human 15-lipoxygenase-1 (15-hLOX-1) inhibitors. Radical scavenging potency of the synthetic allylphenol derivatives was assessed and the results were in accordance with lipoxygenase (LOX) inhibition potency. It was found that the electronic natures of allyl moiety and para substituents play the main role in radical scavenging activity and subsequently LOX inhibition potency of the synthetic inhibitors. Among the synthetic compounds, 2,6-diallyl-4-(hexyloxy)phenol (42) and 2,6-diallyl-4-aminophenol (47) showed the best results for LOX inhibition (IC50 = 0.88 and 0.80 μM, respectively).

": A Jack of Trio "-robust one-pot metal free oxidative amination, azidation and peroxidation of phenols

Herein we disclose a highly efficient methodology for the generation of nitrogen containing quaternary carbon centres via aminative and azidative oxidative dearomatization of phenols. The same protocol has also been successfully employed to achieve oxidative peroxidation of phenols. The simplest metal free reaction conditions delineate an easy breakthrough to the "Trio"- oxidative amination, azidation and peroxidation. An array of diverse polyfunctionalised heterocycles has been synthesized in one pot.