515137-89-0

Basic information

• Product Name: 4-(2-nitrophenethyl)morpholine
• Synonyms: 4-(2-nitrophenethyl)morpholine
• CAS NO: 515137-89-0
• Molecular Weight: 236.271
• Mol File: 515137-89-0.mol

Chemical Properties

• CAS DataBase Reference: 4-(2-nitrophenethyl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-nitrophenethyl)morpholine(515137-89-0)
• EPA Substance Registry System: 4-(2-nitrophenethyl)morpholine(515137-89-0)

Safety Data

• Hazardous Substances Data: 515137-89-0(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 579-71-5 2-nitrostyrene 
• 16793-89-8 (2-bromoethyl)-2-nitrobenzene 

Downstream Products

• 515137-88-9 2-[2-(4-morpholinyl)ethyl]aniline 

Relevant articles and documents

Nucleophilic additions to polarized vinylarenes

The addition of nucleophiles to the terminal double bond carbon of a styrene incorporating an electron-withdrawing group at the ortho or para position has been studied. The conditions for this transformation have been optimized and structural modifications to the substrate have been explored. The structural changes included variation of the activating group on the aromatic ring and positioning substituents on the side chain double bond. The study revealed that nitro substitution gave the best results for addition of carbon and nitrogen nucleophiles. Cyano-substituted systems added carbon nucleophiles, but underwent polymerization or degradation with nitrogen nucleophiles. Ethoxycarbonyl-bearing substrates reacted primarily at the ester carbonyl. The reaction generally proceeded well with methyl on the α carbon of the double bond, but was slowed by methyl at the β position. The yields varied from 50% to 97% for 22 examples.

DIKETOPIPERAZINE DERIVATIVES AS P2X7 MODULATORS

The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein: A represents an aryl, heteroaryl or heterocyclyl group; and any ring or ring system of said aryl or heteroaryl is optionally substituted with 1 to 3 substituents, which may be the same or different, selected from the group consisting of halogen, C1-6 alkyl, -CF3, - OCF3, cyano, C1-6 alkoxy, -NR10R11, -X-aryl, -X-heteroaryl and -X-heterocyclyl; R1, R2, R3, R4 and R5 independently represent hydrogen, fluorine, chlorine, -CF3, cyano or C1-6 alkyl, such that at least one of R1, R2, R3, R4 and R5 is other than hydrogen; R6, R7, R8, R9, R10 and R11 independently represent hydrogen or C1-6 alkyl; X represents a linker selected from a bond, -(CH2)n- and -O-(CH2)n-; and n represents an integer from 1 to 3. The compounds or salts modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor ("P2X7 receptor antagonists").