515154-31-1

Upstream product

• 217487-18-8 1-methanesulfonylpiperidine-4-carboxylic acid ethyl ester 
• 1126-09-6 4-carbethoxypiperidine 
• 124-63-0 methanesulfonyl chloride 
• 25519-80-6 4-(benzoyl)piperidine hydrochloride 
• 241134-34-9 (1-(methylsulfonyl)piperidin-4-yl)methanol 
• 241134-35-0 1-(methylsulfonyl)-4-piperidinecarboxaldehyde 
• 37586-22-4 4-benzoylpiperidine 

Downstream Products

• 916976-44-8 4-[1-(4-fluorophenyl)benzylidene]-1-(methylsulfonyl)-piperidine 
• 833491-20-6 ethyl 3-phenyl-3-(N-methanesulphonylpiperidin-4-yl)acrylate 
• 833491-19-3 ethyl 3-phenyl-3-(N-methanesulphonylpiperidin-4-yl)acrylate 
• 718610-16-3 N-(3-phenyl-3-[1-methanesulphonyl-piperidin-4-yl]propyl)-4-[2-(4-fluorophenylsulphonyl)ethyl]piperidine 
• 718610-64-1 ethyl 3-phenyl-3-(N-methanesulphonylpiperidin-4-yl)propionate 
• 718610-17-4 3-(1-methanesulphonylpiperidin-4-yl)-3-phenylpropionaldehyde 
• 718610-63-0 ethyl 3-phenyl-3-(N-methanesulphonylpiperidin-4-yl)acrylate 
• 916976-31-3 4-benzhydrylidene-1-methanesulfonyl-piperidine 
• 916976-43-7 4-[1-(3-methoxyphenyl)benzylidene]-1-(methylsulfonyl)-piperidine 

Relevant academic research and scientific papers

Synthesis of diarylazepan-4-ones

Synthesis of several 3,3-diarylazepan-4-ones and 5,5-diarylazepan-4-ones has been established starting from two tetrasubstituted olefins, which is derived from commercially available piperidine-3-carboxylic acid ethyl ester and piperidine-4-carboxylic aci

NOVEL PIPERIDINE/8-AZABICYCLO [3.2.1] OCTAN DERIVATIVES AS MODUILATORS OF CHEMOKINE RECEPTOR CCR5

Compounds of formula (I) wherein neither R4 nor R5 is hydrogen; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).

CAN-mediated rearrangement of 4-benzhydrylidenepiperidines

Several 1-substituted phenyl-(4-phenylpiperidin-4-yl)methanones are synthesized in modest overall yields starting from the reaction of different 1-substituted 4-benzhydrylidenepiperidines via CAN-mediated rearrangement. This facile strategy was also used to synthesize meperidine analog.

PIPERIDINE OR 8-AZA-BICYCLO[3.2.1]OCT-3-YL DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Compounds of formula (I): wherein R1, R2, R3, R4, A and n are as defined; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activit

PIPERIDINE DERIVATIVES AS CCR5 RECEPTOR MODULATORS

Compounds of formula (I) wherein R1, R2, R3, A and n are as defined; and X is S(O)2 NR4R5 or NR6S(O)2R7; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).

NOVEL PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5

Compounds of formula (I): wherein R1, R2, R3, R4, R5, A and X are as defined herein; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).

NOVEL PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5

Compounds of formula (I) wherein R1, R2, R3, R4, A, X, m and n are as defined; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).