672-81-1

Usage

Uses

Used in Pharmaceutical Industry:
(Methoxymethylene)malononitrile is used as a chemical intermediate for the production of various pharmaceuticals. Its ability to undergo a variety of chemical reactions makes it valuable in the synthesis of different compounds used in the development of medications.
Used in Agrochemical Industry:
(Methoxymethylene)malononitrile is also used as a chemical intermediate in the production of agrochemicals. Its versatility in chemical reactions contributes to the creation of various agrochemical products.

InChI:InChI=1/C5H4N2O/c1-8-4-5(2-6)3-7/h4H,1H3

Upstream product

• 67-56-1 methanol 
• 123-06-8 Ethoxymethylenemalononitrile 
• 109-77-3 malononitrile 
• 149-73-5 trimethyl orthoformate 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 672-25-3 aminomethylene-malononitrile 
• 5515-16-2 2-(methoxyethylidene)propanedinitrile 
• 1107008-22-9 5-amino-1-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbonyl)-1H-pyrazole-4-carbonitrile 
• 1241398-06-0 5-amino-1-(5-(thiophene-2-yl)-1-phenyl-1H-pyrazole-3-carbonyl)-1H-pyrazole-4-carbonitrile 
• 30929-67-0 5-amino-1-cyclopentyl-1H-pyrazole-4-carbonitrile 
• 1350221-90-7 diisopropyl-4,4-dicyano-3-(cyclohexylimino)-5-methoxycyclopent-1-ene-1,2-dicarboxylate 
• 1350221-93-0 dineopantyl-4,4-dicyano-3-(cyclohexylimino)-5-methoxycyclopent-1-ene-1,2-dicarboxylate 
• 1350221-87-2 dimethyl-4,4-dicyano-3-(cyclohexylimino)-5-methoxycyclopent-1-ene-1,2-dicarboxylate 
• 1350221-89-4 diethyl-4,4-dicyano-3-(cyclohexylimino)-5-methoxycyclopent-1-ene-1,2-dicarboxylate 
• 51516-70-2 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 
• 16617-46-2 3-amino-4-cyano-2H-pyrazole 
• 16617-46-2 3-Amino-4-cyanopyrazole 
• 698-29-3 2-methyl-4-amino-5-cyanopyrimidine 
• 5334-41-8 5-amino-4-cyano-1-methylpyrazole 

Relevant academic research and scientific papers

Preparation method and applications of azimsulfuron key intermediate

The present invention provides a preparation method of 1-methyl-4-(2-methyl-2H-tetrazole-5-yl)1H-pyrazole-5-sulfamide. The preparation method comprises that trimethyl orthoformate and malononitrile are adopted as starting raw materials, a three-step reaction is performed to obtain 1-methyl-5-amino-4-(tetrazole-5-yl)pyrazole, the 1-methyl-5-amino-4-(tetrazole-5-yl)pyrazole reacts with dimethylsulfate in the presence of an acid-binding agent to obtain 2-methyl-5-(1-methyl-5-amino-1H-pyrazole-4-yl)-2H-tetrazole, the 2-methyl-5-(1-methyl-5-amino-1H-pyrazole-4-yl)-2H-tetrazole is subjected to a sodium nitrite diazo-reaction under an acid condition, the obtained material reacts with a sodium sulfite-copper chloride-acetic acid mixture, and finally hydrolysis with ammonia is performed to obtain the target product. The present invention further provides a preparation method of azimsulfuron prepared from the 1-methyl-4-(2-methyl-2H-tetrazole-5-yl)1H-pyrazole-5-sulfamide. The preparation method of the present invention has characteristics of short reaction route, environmental protection raw materials, and high yield.

NMR spectroscopic data of some 1-alkoxy-2,2-di(carbonyl, carboxyl, cyano)-substituted ethylenes

The 1H-13C NMR shifts as well as 1H and 13C coupling constants of 14 alkoxymethylene malonic acid and acetoacetic acid derivatives and two alkoxymethylene acetylacetones are reported. The 17O NMR spectra have been recorded for six of them. The long-range coupling 3J(H-C=C-CR) has been used for determining the stereochemistry of the double bond. Copyright