515173-95-2Relevant academic research and scientific papers
An efficient method for the stereoselective synthesis of cis-3-substituted prolines: Conformationally constrained α-amino acids
Flamant-Robin, Céline,Wang, Qian,Chiaroni, Angèle,Sasaki, N. André
, p. 10475 - 10484 (2007/10/03)
An efficient synthesis of enantiomerically pure cis-3-substituted prolines is reported. Key steps involve the stereoselective organocuprate addition to the (E)-α,β-unsaturated ester 1, obtained from the Garner's aldehyde, and expedient oxidation-cyclizati
