51528-32-6

Basic information

• Product Name: ethylmethylphosphinic acid
• Synonyms: ethylmethylphosphinic acid;Einecs 257-254-2
• CAS NO: 51528-32-6
• Molecular Formula: C₃H₉O₂P
• Molecular Weight: 108.076121
• EINECS: 257-254-2
• Mol File: 51528-32-6.mol

Chemical Properties

• Melting Point: 7-8 °C
• Boiling Point: 297.8°Cat760mmHg
• Flash Point: 133.9°C
• Appearance: /
• Density: 1.083g/cm³
• Vapor Pressure: 0.000316mmHg at 25°C
• Refractive Index: 1.403
• PKA: 3.04±0.50(Predicted)
• CAS DataBase Reference: ethylmethylphosphinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: ethylmethylphosphinic acid(51528-32-6)
• EPA Substance Registry System: ethylmethylphosphinic acid(51528-32-6)

Safety Data

• Hazardous Substances Data: 51528-32-6(Hazardous Substances Data)

Usage

Uses

Used in Nuclear Fuel Reprocessing:
Ethylmethylphosphinic acid is used as a chelating agent in the production of solvents for nuclear fuel reprocessing. It helps in the separation and purification of radioactive elements, ensuring the safe and efficient processing of nuclear materials.
Used in Hydrometallurgy:
In the field of hydrometallurgy, EMPA serves as a complexing agent for the separation of actinides and lanthanides. Its ability to form stable complexes with these elements facilitates their extraction and purification, contributing to the efficient recovery of valuable metals.
Used in Metal Poisoning Treatment:
Ethylmethylphosphinic acid has been studied for its potential use in the treatment of metal poisoning. Its chelating properties allow it to bind with toxic metal ions, aiding in their removal from the body and providing a possible therapeutic solution for heavy metal intoxication.
Used as a Precursor in Organic Synthesis:
EMPA also serves as a precursor in the synthesis of various organic compounds. Its unique chemical structure and reactivity make it a valuable building block for the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.

InChI:InChI=1/C3H9O2P/c1-3-6(2,4)5/h3H2,1-2H3,(H,4,5)

Upstream product

• 30405-01-7 methyl-ethyl-phosphinic acid isobutyl ester 
• 15715-41-0 methyldiethoxyphosphine 
• 74-85-1 ethene 
• 4206-94-4 methylphosphinic acid 
• 29786-16-1 ethyl-phosphonic acid-chloride dimethylamide 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 51528-37-1 ethylmethylphosphinic acid anhydride 

Relevant articles and documents

METHYLPHOSPHINIC ACID COMPOSITIONS AND METHODS FOR REDUCING AGING

A composition that includes methylphosphinic acid or a salt thereof, and optionally methylphosphonic acid or a salt thereof, and an ingredient acceptable for consumption by a mammal is provided herein. Also provided is a method for reducing aging in a mammal that involves providing or administering methylphosphinic acid or a salt thereof, and optionally, methylphosphonic acid or a salt thereof, to the mammal in need thereof for consumption. A composition for use in such a method and an article useful for such a method include those in the form of a food product such as a prepackaged or processed food or meal, a beverage, a nutritional supplement, or a nutraceutical.

Preparation method for methylethylphosphinic acid and aluminum salt thereof

The invention discloses a preparation method for methylethylphosphinic acid and an aluminum salt thereof, belonging to the technical field of organic synthesis. To reduce the production cost of methylethylphosphinic acid and improve the purity of methylethylphosphinic acid, the invention provides the preparation method for methylethylphosphinic acid and the aluminum salt thereof. The preparation method comprises the following steps: reacting dichloromethylphosphine with water to obtain an aqueous dichloromethylphosphine solution; with di-tert-butyl peroxide as an initiator, reacting the aqueous dichloromethylphosphine solution with ethylene so as to obtain methylethylphosphinic acid; and reacting the methylethylphosphinic acid with an aqueous solution of Al(SO).18HO to obtain the aluminum salt of methylethylphosphinic acid. According to the invention, the aqueous dichloromethylphosphine solution is directly used for preparing the methylethylphosphinic acid, reaction conditions are screened so as to realize high-yield preparation of high-purity methylethylphosphinic acid, and the high-purity methylethylphosphinic acid is directly used for preparing the aluminum salt of methylethylphosphinic acid; so the purification operation of each intermediate is eliminated, which allows production efficiency to be significantly improved and production cost to be reduced.

Process for preparing dialkylphosphinic acids and their salts

The invention relates to a process for the preparation of dialkylphosphinic acids and salts thereof, which comprises a) reacting elemental yellow phosphorus with alkylating agents in the presence of a base to give a mixture which comprises, as principal constituents, the (metal) salts of alkylphosphonous, phosphorous and hypophosphorous acids, b) esterifying the principal constituents of the mixture from a) to give an ester mixture, c) isolating the ester of the alkylphosphonous acid from the ester mixture, d) preparing the corresponding ester of the dialkylphosphinic acid from the ester of the alkylphosphonous acid by free-radical-initiated reaction with olefins, e) converting the ester of the dialkylphosphinic acid into the free acid or into the dialkylphosphinic acid salts of metals from groups IA, IIA, IIIA, IVA, VA, IIB, IVB, VIIB or VIIIB of the Periodic Table or of cerium. The invention likewise relates to the use of the dialkylphosphinic acids/salts prepared by this process for the preparation of various products, in particular flame retardants.

Process for preparing salts of dialkylphosphinic acids

The invention relates to a process for preparing salts of dialkylphosphinic acids, which comprisesa) reacting alkylphosphonous and/or hypophosphorous acid and/or alkali metal salts thereof with olefins in the presence of a free-radical initiator to give dialkylphosphinic acids and/or alkali metal salts thereof andb) reacting the dialkylphosphinic acids and/or alkali metal salts thereof obtained according to a) with metal compounds of Mg, Ca, Al, Sb, Sn, Ge, Ti, Zn, Fe, Zr, Ce, Bi, Sr, Mn, Li, Na and/or K to give the metal dialkylphosphinate salts.The invention likewise relates to the use of the metal dialkylphosphinate salts prepared by the process according to the invention for preparing flame retardants.

UEBER EINIGE REAKTIONEN DER DIALKYLBENZYLPHOSPHINIMIDE

Dialkylbenzylphosphine imides C6H5CH2-PRR'=NR'' (R,R'=CH3, C2H5; R''=H, CH3, Si(CH3)3) react with aliphatic and aromatic aldehydes in benzene solution on heating to 80 deg C directly and in high yields according to a Horner-Wittig-reaction with formation of an olefine whereas ketones like benzophenone and acetophenone only perform an O/NR'' exchange (R''=H).