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N-(1-Benzyl-4-piperidinyl)-N-phenylpropanamide HCl is a complex organic compound with the chemical formula C23H28ClN2O. It is a derivative of propanamide, featuring a benzyl group attached to a piperidine ring and a phenyl group connected to the propanamide backbone. N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl is known for its potential applications in the pharmaceutical industry, particularly as a precursor in the synthesis of certain drugs. It is characterized by its ability to interact with biological targets, such as receptors or enzymes, which may lead to therapeutic effects. The hydrochloride salt form of the compound enhances its solubility and stability, which is often desirable for pharmaceutical applications.

5156-58-1

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5156-58-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5156-58-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,5 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5156-58:
(6*5)+(5*1)+(4*5)+(3*6)+(2*5)+(1*8)=91
91 % 10 = 1
So 5156-58-1 is a valid CAS Registry Number.

5156-58-1Relevant academic research and scientific papers

Synthesis and comparative bioefficacy of N-(1-phenethyl-4-piperidinyl) propionanilide (fentanyl) and its 1-substituted analogs in Swiss albino mice

Gupta, Pradeep Kumar,Yadav, Shiv Kumar,Bhutia, Yangchen Doma,Singh, Poonam,Rao, Pooja,Gujar, Niranjan Laxman,Ganesan, Kumaran,Bhattacharya, Rahul

, p. 3888 - 3896 (2013/07/26)

Fentanyl [N-(1-phenethyl-4-piperidinyl)propionanilide] is a popular narcotic analgesic agent that is clinically used worldwide. However, fentanyl and its several analogs have caused abuse and fatalities in humans due to overdosing and narrow therapeutic index. The present study reports the synthesis and comparative bioefficacy of fentanyl and its four analogs, viz., N-(1-propyl-4-piperidinyl)propionanilide (1), N-(1-(2-phenoxyethyl)-4- piperidinyl)propionanilide (2), N-(1-(3-phenoxypropyl)-4-piperidinyl) propionanilide (3) and N-(1-(2-cyanoethyl)-4-piperidinyl)propionanilide (4), where the phenethyl chain of fentanyl was replaced by different functional groups, viz., alkyl, ethereal, and nitrile moieties. The median lethal dose (LD50) of the compounds was determined by three different routes and all the analogs were found to be safer than fentanyl. Observational assessment on spontaneous activities of the central nervous system, peripheral nervous system, and autonomic nervous system revealed that all the analogs were similar to fentanyl. Further, the neurotoxic effects of all the analogs were reversed by naloxone hydrochloride (opioid antagonist), confirming that their effects were mediated through opioid receptors. Antinociceptive activity was displayed by all the compounds and their median effective dose (ED50) and analgesic potency ratio were more or less similar to fentanyl. The lowest ED50 (23.7) and the highest potency ratio (1.18) was observed in the case of 2. However, the maximum therapeutic index was afforded by 4. The study indicates the promising role of some new opioid analgesics.