51564-29-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-3-cyano-6-methoxy-4-methylpyridine is used as an intermediate for the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
2-Chloro-3-cyano-6-methoxy-4-methylpyridine is used as a building block for the production of insecticides and herbicides. Its incorporation into these agrochemicals helps in the development of effective pest control solutions for agricultural purposes.
Safety Precautions:
2-Chloro-3-cyano-6-methoxy-4-methylpyridine is considered a hazardous substance and should be handled with care. Exposure to high concentrations can cause irritation to the skin, eyes, and respiratory tract. Proper safety measures, such as wearing protective gear and working in well-ventilated areas, should be taken to minimize potential health risks.

Upstream product

• 186581-53-3 diazomethane 
• 262606-83-7 methyl (2,6-dichloro-3-{[methyl(pent-4-enyl)amino]carbonyl}pyridin-4-yl)acetate 
• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 875-35-4 2,6-dichloro-4-methylnicotinonitrile 

Relevant academic research and scientific papers

SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES FOR TREATING NEUROLOGICAL AND NEURODEGENERATIVE DISEASES

The present invention provides, in part, compounds of Formula (I): or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N- oxide, wherein: R1, R2, L, A, and E are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4- associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.

SUBSTITUTED NITROGEN CONTAINING COMPOUNDS

Disclosed are compounds of Formula (I): or a salt thereof, Formula (II) wherein R1 is: or; each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

NEW TRPA1 ANTAGONISTS

The present invention relates to bicyclic heterocyclic derivatives of Forrmula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by TRPA1 channel inhibition or antagonism.

NEW TRPA1 ANTAGONISTS

The present invention relates to compounds of Formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by TRPA1 channel inhibition or antagonism.

NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

This invention relates to novel pyridine derivatives having an inhibitory effect on production of cytokines, which are involved in inflammatory responses, thus suggesting its usefulness as therapeutic agents for treating diseases related to inflammation, immune, chronic inflammation as well as an agent having an anti-inflammatory and analgesic effect. Further, this invention relates to a method of manufacturing the same and a pharmaceutical composition containing the same.

A novel approach to conformationally restricted analogues of nicotine and anabasine by an intramolecular Hamaguchi-Ibata reaction

A short synthesis of methyl (SR)-8,10-dichloro- 1,2,3,4,5,6-hexahydro-6- hydroxy-1-methyl-1,9-phenanthroline-6-carboxylate (14) has been achieved en route to conformationally restricted analogues of nicotine and anabasine. The key feature of this process involves an efficient intramolecular Hamaguchi- Ibata reaction of 11. (C) 2000 Elsevier Science Ltd.

Studies on the preparation of 3,4-disubstituted 2-methoxypyridines

The synthesis of 2-methoxy-4-methylpyridine-3-carbonitrile (3) and its conversion, by way of alkylation of the C(4) methyl group, into the pyridyl acetic acid ester 6 is described.