5157-13-1Relevant academic research and scientific papers
A convenient preparation of symmetrical and unsymmetrical 1,2-diketones: Application to fluorinated phenytoin synthesis
Page,Graham,Park
, p. 7265 - 7274 (2007/10/02)
1,2-Diketones are efficiently produced in two steps by reaction of aldehydes with anions derived from 2-substituted dithianes followed by treatment of the resulting alcoholis with NBS in aqueous acetone; phenytoin derivatives were prepared from these diketones by a standard method involving treatment with urea and potassium hydroxide under reflux.
Concerning the reaction mechanism of the hydantoin synthesis according to Biltz, I: Proof of the intermediates
Schwenker,Guo,Bernhart
, p. 779 - 783 (2007/10/02)
The reaction mechanism of the rearrangement occurring during the hydantoin synthesis according to Biltz, proposed by Butler and Leitch, has been ascertained. The intermediate 3a, already proposed by Biltz, could be isolated out of the reaction mixture. Th
