16107-85-0

Upstream product

• 5722-91-8 1,2-diphenyl-2-(phenylamino)ethanone 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 134-81-6 benzil 
• 1484-50-0 desyl bromide 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 451-40-1 phenyl benzyl ketone 
• 578-46-1 5-methyl-2-nitroaniline 
• 89-62-3 4-methyl-2-nitroaniline 
• 501-65-5 diphenyl acetylene 
• 492-70-6 1,2-diphenyl-1,2-ethanediol 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 100-52-7 benzaldehyde 
• 64-17-5 ethanol 
• 5157-13-1 4,5-Dihydroxy-4,5-diphenylimidazolidin-2-on 

Downstream Products

• 308145-34-8 6-bromomethyl-2,3-diphenylquinoxaline 
• 1582317-81-4 (2-(7-methyl-3-phenylquinoxalin-2-yl)phenyl)(phenyl)methanone 
• 1582317-80-3 (2-(6-methyl-3-phenylquinoxalin-2-yl)phenyl)(phenyl)methanone 
• 1296867-23-6 C₂₅H₂₀N₂O₄ 
• 24249-63-6 6-vinyl-2,3-diphenylquinoxaline 

Relevant academic research and scientific papers

An efficient and facile synthesis of quinoxaline derivatives catalyzed by KHSO4 at room temperature

A facile synthesis of quinoxaline derivatives catalyzed by KHSO4 in very high yields at room temperature is reported.

Easy access to quinoxaline derivatives using alumina as an effective and reusable catalyst under solvent-free conditions

Alumina as a cheap, heterogeneous and reusable catalyst can provide environmentally friendly alternatives for synthesis of quinoxaline derivatives via condensation of 1,2-diamines and 1,2-dicarbonyl compounds under solvent-free conditions. The products could be separated simply from catalyst by filtration and the catalyst could be recycled and reused for several times without noticeably decreasing in catalytic activity.

MnCl2-promoted synthesis of quinoxaline derivatives at room temperature

MnCl2 efficiently catalyzes the condensation of o-phenylenediamine derivatives with 1,2-diketones at room temperature to afford the corresponding quinoxaline derivatives in high yields.

A zirconium Schiff base complex immobilized on starch-coated maghemite nanoparticles catalyzes heterogeneous condensation of 1,2-diamines with 1,2-dicarbonyl compounds

A magnetically separable zirconium Schiff base nanocatalyst was synthesized under ultrasonic agitation. TEM images revealed a uniform spherical particle shape with average size of 10-14 nm for the as-prepared catalyst. The catalytic performance of ZrOL2@SMNP in the heterogeneous condensation of various 1,2-diamines and 1,2-dicarbonyls for the synthesis of heterocyclic compounds in ethanol has been explored.

Efficient route to quinoxalines catalyzed by sulfamic acid in tap water suspension

Quinoxalines were synthesized via direct condensations of o-phenylenediamines with α-diketones promoted by sulfamic acid at room temperature in tap water suspension in high yields and by simple work-up.

Polyaniline/SiO2 nanocomposite catalyzed efficient synthesis of quinoxaline derivatives at room temperature

Polyaniline/SiO2 nanocomposite material has been synthesized by using chemical oxidative method. Prepared catalytic material was characterized by means of transmission electron microscopy (TEM), thermal analysis (TG-DTA), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and Fourier transform infrared spectroscopy (FT-IR). Solvent stability for the catalyst has been screened using UV-Visible spectroscopy. Polyaniline/SiO2 catalyzed route has found to be an efficient and rapid protocol for the synthesis of quinoxaline derivatives by cyclocondensation of 1,2-diketones and o-phenylenediamines at room temperature. This protocol has several advantages such as high yield, good thermal stability, simple work up procedure, non-toxic, clean, and easy recovery and reusability of the catalytic system.

Tungstophosphoric acid/mesoporous silicas as suitable catalysts in quinoxaline synthesis

Quinoxalines and their derivatives are of great value in the chemical and biological sciences. These compounds are found in dyes, agrochemicals, and are used as building blocks of drugs for the treatment of different diseases. Quinoxalines and their deriv

In water organic synthesis: Introducing itaconic acid as a recyclable acidic promoter for efficient and scalable synthesis of quinoxaline derivatives at room temperature

Substituted quinoxaline derivatives are traditionally synthesized by co-condensation of various starting materials. Herein, we describe a novel environmentally benign in water synthetic route for the synthesis of structurally and electronically diverse ninety quinoxalines with readily available substituted o-phenylenediamine and 1,2-diketones using cheap and biodegradable itaconic acid as a mild acid promotor in 1 hours. The reaction is performed at room temperature, which proceeds through cyclo-condensation reaction followed by obtaining the aforesaid nitrogen-containing heterocyclic adducts without performing the column chromatography up to 96% total yields. The simplicity, high efficiency, and reusable of the catalyst merits this reaction condition as “green synthesis” which enables it to be useful in synthetic transformations upto gram scale level.

An efficient and green procedure for the synthesis of quinoxaline derivatives using 3,5-bis(Trifluoromethyl)phenylammonium triflate (bfpat) organocatalyst

The application of 3,5-bis(trifluoromethyl)phenylammonium triflate (BFPAT) as a conven-ient new organocatalyst for the synthesis of quinoxaline derivatives is described. In the presence of BFPAT, one-pot synthesis of a wide variety of quinoxaline derivati

Green Hydrothermal Synthesis of Fluorescent 2,3-Diarylquinoxalines and Large-Scale Computational Comparison to Existing Alternatives

Here, the hydrothermal synthesis (HTS) of 2,3-diarylquinoxalines from 1,2-diketones and o-phenylendiamines (o-PDAs) was achieved. The synthesis is simple, fast, and generates high yields, without requiring any organic solvents, strong acids or toxic catalysts. Reaction times down to 90 % in all cases). Moreover, it was shown that HTS has high compatibility: (i) hydrochlorides, a standard commercial form of amines, could be used directly as combined amine source and acidic catalyst, and (ii) Boc-diprotected o-PDA could be directly employed as substrate that underwent HT deprotection. A systematic large-scale computational comparison of all reported syntheses of the presented quinoxalines from the same starting compounds showed that this method is more environmentally friendly and less toxic than all existing methods and revealed generic synthetic routes for improving reaction yields. Finally, the application of the synthesized compounds as fluorescent dyes for cell staining was explored.