16107-85-0Relevant academic research and scientific papers
An efficient and facile synthesis of quinoxaline derivatives catalyzed by KHSO4 at room temperature
Oskooie, Hossein A.,Heravi, Majid M.,Bakhtiari, Khadijeh,Taheri, Shima
, p. 875 - 877 (2007)
A facile synthesis of quinoxaline derivatives catalyzed by KHSO4 in very high yields at room temperature is reported.
Easy access to quinoxaline derivatives using alumina as an effective and reusable catalyst under solvent-free conditions
Jafarpour, Maasoumeh,Rezaeifard, Abdolreza,Danehchin, Maryam
, p. 48 - 51 (2011)
Alumina as a cheap, heterogeneous and reusable catalyst can provide environmentally friendly alternatives for synthesis of quinoxaline derivatives via condensation of 1,2-diamines and 1,2-dicarbonyl compounds under solvent-free conditions. The products could be separated simply from catalyst by filtration and the catalyst could be recycled and reused for several times without noticeably decreasing in catalytic activity.
MnCl2-promoted synthesis of quinoxaline derivatives at room temperature
Heravi, Majid M.,Bakhtiari, Khadijeh,Oskooie, Hossein A.,Taheri, Shima
, p. 218 - 220 (2008)
MnCl2 efficiently catalyzes the condensation of o-phenylenediamine derivatives with 1,2-diketones at room temperature to afford the corresponding quinoxaline derivatives in high yields.
A zirconium Schiff base complex immobilized on starch-coated maghemite nanoparticles catalyzes heterogeneous condensation of 1,2-diamines with 1,2-dicarbonyl compounds
Jafarpour, Maasoumeh,Rezaeifard, Abdolreza
, p. 205 - 211 (2016)
A magnetically separable zirconium Schiff base nanocatalyst was synthesized under ultrasonic agitation. TEM images revealed a uniform spherical particle shape with average size of 10-14 nm for the as-prepared catalyst. The catalytic performance of ZrOL2@SMNP in the heterogeneous condensation of various 1,2-diamines and 1,2-dicarbonyls for the synthesis of heterocyclic compounds in ethanol has been explored.
Efficient route to quinoxalines catalyzed by sulfamic acid in tap water suspension
Li, Zhenjiang,Li, Weisi,Ren, Xinghua,Sun, Yingjie,Shi, Yuhu,Ouyang, Pingkai
, p. 125 - 130 (2007)
Quinoxalines were synthesized via direct condensations of o-phenylenediamines with α-diketones promoted by sulfamic acid at room temperature in tap water suspension in high yields and by simple work-up.
Polyaniline/SiO2 nanocomposite catalyzed efficient synthesis of quinoxaline derivatives at room temperature
Yelwande, Ajeet A.,Navgire, Madhukar E.,Arbad, Balasaheb R.,Lande, MacHhindra K.
, p. 995 - 1000 (2012)
Polyaniline/SiO2 nanocomposite material has been synthesized by using chemical oxidative method. Prepared catalytic material was characterized by means of transmission electron microscopy (TEM), thermal analysis (TG-DTA), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and Fourier transform infrared spectroscopy (FT-IR). Solvent stability for the catalyst has been screened using UV-Visible spectroscopy. Polyaniline/SiO2 catalyzed route has found to be an efficient and rapid protocol for the synthesis of quinoxaline derivatives by cyclocondensation of 1,2-diketones and o-phenylenediamines at room temperature. This protocol has several advantages such as high yield, good thermal stability, simple work up procedure, non-toxic, clean, and easy recovery and reusability of the catalytic system.
Tungstophosphoric acid/mesoporous silicas as suitable catalysts in quinoxaline synthesis
Langer, Peter,Luque, Rafael,Palermo, Valeria,Pizzio, Luis R.,Romanelli, Gustavo P.,Sosa, Alexis A.
, (2021/12/16)
Quinoxalines and their derivatives are of great value in the chemical and biological sciences. These compounds are found in dyes, agrochemicals, and are used as building blocks of drugs for the treatment of different diseases. Quinoxalines and their deriv
Ruthenium?p-cymene complexes with acylthiourea, and its heterogenized form on graphene oxide act as catalysts for the synthesis of quinoxaline derivatives
Bhuvanesh, Nattamai,Gopiraman, Mayakrishnan,Karvembu, Ramasamy,Sindhuja, Dharmalingam,Vasanthakumar, Punitharaj
, (2021/06/30)
Synthesis of a series of half-sandwich Ru(II) complexes (1-5) containing acylthiourea ligand is reported herein. All the Ru(II) complexes were well characterized by analytical and spectroscopic (UV-Vis, FT-IR, NMR and mass spectrometry) methods. Molecular structures of two (2 and 3) of the complexes were confirmed by single crystal X-ray diffraction, and the complexes adopted pseudo-octahedral geometry around Ru. Catalytic ability of the Ru complexes was evaluated in the synthesis of quinoxaline compounds from various 2-nitroaniline and hydroxy ketone derivatives via transfer hydrogenation approach. Active homogeneous catalyst was heterogenized by supporting it on graphene oxide, and the heterogeneous equivalent was characterized by Raman, XPS, TEM, SEM and ICP-OES techniques. Activity of the heterogeneous catalyst was tested, and it can be reused up to five cycles without any loss in activity.
NaOH-Mediated Direct Synthesis of Quinoxalines from o-Nitroanilines and Alcohols via a Hydrogen-Transfer Strategy
Wang, Yan-Bing,Shi, Linlin,Zhang, Xiaojie,Fu, Lian-Rong,Hu, Weinan,Zhang, Wenjing,Zhu, Xinju,Hao, Xin-Qi,Song, Mao-Ping
, p. 947 - 958 (2021/01/14)
A NaOH-mediated sustainable synthesis of functionalized quinoxalines is disclosed via redox condensation of o-nitroamines with diols and α-hydroxy ketones. Under optimized conditions, various o-nitroamines and alcohols are well tolerated to generate the desired products in 44-99% yields without transition metals and external redox additives.
In water organic synthesis: Introducing itaconic acid as a recyclable acidic promoter for efficient and scalable synthesis of quinoxaline derivatives at room temperature
Tamuli, Kashyap J.,Nath, Shyamalendu,Bordoloi, Manobjyoti
supporting information, p. 983 - 1002 (2021/02/27)
Substituted quinoxaline derivatives are traditionally synthesized by co-condensation of various starting materials. Herein, we describe a novel environmentally benign in water synthetic route for the synthesis of structurally and electronically diverse ninety quinoxalines with readily available substituted o-phenylenediamine and 1,2-diketones using cheap and biodegradable itaconic acid as a mild acid promotor in 1 hours. The reaction is performed at room temperature, which proceeds through cyclo-condensation reaction followed by obtaining the aforesaid nitrogen-containing heterocyclic adducts without performing the column chromatography up to 96% total yields. The simplicity, high efficiency, and reusable of the catalyst merits this reaction condition as “green synthesis” which enables it to be useful in synthetic transformations upto gram scale level.
