51579-95-4

Basic information

• Product Name: N,N-dimethyl-4-methoxy-α-oxo-benzeneacetamide
• Synonyms: N,N-dimethyl-4-methoxy-α-oxo-benzeneacetamide
• CAS NO: 51579-95-4
• Molecular Weight: 207.229
• Mol File: 51579-95-4.mol

Chemical Properties

• CAS DataBase Reference: N,N-dimethyl-4-methoxy-α-oxo-benzeneacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-4-methoxy-α-oxo-benzeneacetamide(51579-95-4)
• EPA Substance Registry System: N,N-dimethyl-4-methoxy-α-oxo-benzeneacetamide(51579-95-4)

Safety Data

• Hazardous Substances Data: 51579-95-4(Hazardous Substances Data)

Upstream product

• 479486-96-9 N,N-dimethyl (trimethylsilyl)methanamide 
• 68-12-2 N,N-dimethyl-formamide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 110-91-8 morpholine 
• 201230-82-2 carbon monoxide 
• 696-62-8 para-iodoanisole 
• 104-93-8 p-methylanizole 
• 7099-91-4 p-methoxybenzoylformic acid 
• 7465-88-5 4-methoxy-N-phenylbenzamide 
• 124-40-3 dimethyl amine 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 1608-14-6 N,N,N'N'-tetramethyl oxamide 

Downstream Products

• 1051853-18-9 3-(4-methoxyphenyl)-N,N-dimethylpropiolamide 

Relevant articles and documents

Double carbonylation of iodoarenes in the presence of a pyridinium SILP-Pd catalyst

The efficiency of a palladium catalyst, immobilised on a supported ionic liquid phase (SILP) with adsorbed 1-butyl-4-methylpyridinium chloride, was investigated in aminocarbonylation reactions. Double carbonylation was found to be the main reaction using different iodoarenes and aliphatic amines as substrates. Application of aniline derivatives as nucleophiles led to the exclusive formation of substituted benzamides. The stabilisation effect of the adsorbed pyridinium ionic liquid was compared to that of imidazolium and phosphonium derivatives. It was proved that the pyridinium SILP-palladium catalyst could be reused in at least 10 cycles. Recyclability was tested in five successive runs for all of the substrates.

Copper-Catalyzed Oxidative Synthesis of α-Ketoamides from Aryl Methyl Ketones and N -Bromobutanimide Using N, N -Dimethylformamide as Dimethylamine Source

A novel and practical Cu(OAc) 2 -catalyzed oxidative synthesis of α-ketoamides from aryl methyl ketones and N -bromobutanimide (NBS) using N, N -dimethylformamide (DMF) as dimethylamine (HNMe 2) source and solvent has been developed under mild conditions. DMF was used as a HNMe 2 source and can be easily converted into HNMe 2 by acid hydrolysis. The mechanistic studies indicate that Cu(OAc) 2 plays a dual role in providing both catalyst and oxidant.

TBAI-catalyzed synthesis of α-ketoamides via sp3 C-H radical/radical cross-coupling and domino aerobic oxidation

A TBAI-catalyzed one-pot synthesis of α-ketoamides via sp3 C-H radical/radical cross-coupling and domino aerobic oxidation was developed. This synthesis is suitable for abroad range of substrates. The control experiments suggested a possible oxidative coupling mechanism.

Synthesis of α-ketoamides from Aryl methyl ketones and N, N -dimethylformamide via copper-catalyzed aerobic oxidative coupling

A copper-catalyzed aerobic oxidative coupling of aryl methyl ketones with N,N-dimethylformamide was developed, which afforded α-ketoamides by a sequence of dioxygen activation, C-H bond functionalization, and amide formation with N,N-dimethylformamide as

Copper-catalyzed oxidative condensation of α-oxocarboxylic acids with formamides: Synthesis of α-ketoamides

A copper-catalyzed coupling of α-oxocarboxylic acids with formamides is reported. This simple method provides a practical approach toward the synthesis of α-ketoamides with a variety of functional groups. Mechanistic studies have shown that the reaction proceeded via a radical process and 13C-labeled experiments proved that the amide carbon in the products comes from the corresponding carboxylic acid, not from the DMF. is

Cu(ii)-catalyzed decarboxylative acylation of acyl C-H of formamides with α-oxocarboxylic acids leading to α-ketoamides

CuBr2-catalyzed decarboxylative acylation of the acyl C-H of N-monosubstituted and N,N-disubstituted formamides with α-oxocarboxylic acids leading to α-ketoamides was developed, which generated the corresponding products in good yields. The Royal Society of Chemistry 2013.

Direct use of formamides as amino group sources via C-N bond cleavage: A catalytic oxidative synthesis of α-ketoamides from acetophenones and formamides under metal-free conditions

An efficient and direct use of formamides as amino group sources for the synthesis of α-ketoamides was developed under metal-free conditions. The reaction was based on the oxidative coupling of acetophenones with formamides and generated the desired products in good yields in the presence of t-BuOOH/I2/PhCO2H.

Palladium-catalyzed synthesis of α-iminoamides from imidoyl chlorides and a carbamoylsilane

A series of pure imidoyl chlorides were converted into α-iminoamides by treatment with a carbamoylsilane under catalysis by palladium(0) complexes.

Hypervalent iodine in synthesis 68: Palladium-catalysed double carbonylation of diaryliodonium salts to give α-keto-amides

In the presence of a palladium catalyst and the cocatalyst Cul, several diaryliodonium salts have been converted into α-keto amides on treatment with secondary amines and carbon monoxide in good yield and selectivity under mild reaction conditions.