515845-28-0Relevant articles and documents
PYRAZOLYLPHENYL AND PYRROLYLPHENYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION
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Page/Page column 8, (2010/11/29)
Two chemical genera of pyrazolylphenyl and pyrrolylphenyl derivatives are disclosed. They have the general formula: In these compounds ring (a) is a pyrazole or pyrrole; Q is selected from the group consisting of a direct bond, O, S, SO, SO2, N
Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N-[3-fluoro-2′ -(aminosulfonyl)[1,1′-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor
Pruitt, James R.,Pinto, Donald J. P.,Galemmo Jr., Robert A.,Alexander, Richard S.,Rossi, Karen A.,Wells, Brian L.,Drummond, Spencer,Bostrom, Lori L.,Burdick, Debra,Bruckner, Robert,Chen, Haiying,Smallwood, Angela,Wong, Pancras C.,Wright, Matthew R.,Bai, Steven,Luettgen, Joseph M.,Knabb, Robert M.,Lam, Patrick Y. S.,Wexler, Ruth R.
, p. 5298 - 5315 (2007/10/03)
Factor Xa, a serine protease, is at the critical juncture between the intrinsic and extrinsic pathways of the coagulation cascade. Inhibition of factor Xa has the potential to provide effective treatment for both venous and arterial thrombosis. We recentl