51664-96-1

Upstream product

• 67-56-1 methanol 
• 58085-75-9 2,4,5-trimethylbenzotrichloride 
• 528-90-5 2,4,5-trimethylbenzoic acid 
• 74-88-4 methyl iodide 
• 936-02-7 2-Hydroxybenzoylhydrazine 
• 201230-82-2 carbon monoxide 
• 95-63-6 1,2,4-Trimethylbenzene 

Relevant academic research and scientific papers

DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS

In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (ll).

Reactions of trichloromethylarenes with hydrazine derivatives. Synthesis of 2,5-disubstituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles

The effect of the solvent on the course of the reaction between trichloromethylarenes and thioacylhydrazines or acylhydrazines has been considered. In alcohols as solvents, alkyl arenecarboxylates form as a result of alcoholysis, while 2,5-disubstituted 1,3,4-thiadiazoles (1,3,4-oxadiazoles) form as minor products. In pyridine solutions, the major or sole products are those of reductive condensation, i.e., the corresponding N-substituted hydrazones of arenecarbaldehydes. 1,3,4-Thiadiazole or 1,3,4-oxadiazole derivatives are obtained in good yield when the reaction is carried out in a pyridine - alkanol mixture.

Carbonylation of Organomercury Compounds: A General Synthesis of Carboxylic Acids and Esters

Organomercury compounds react with carbon monoxide in aqueous or alcoholic media to give good yields of carboxylic acids or esters.The carboxyl group is introduced selectively at the site of the carbon-mercury bond.Homogeneous group 9 and 10 metal complexes catalyze this carbonylation reaction, which yields mercury(0) as the inorganic byproduct.The mercuration-carbonylation sequence represents a general synthesis of carboxylic acids and esters.