528-90-5

Usage

Uses

Used in Chemical Synthesis:
2,4,5-Trimethylbenzoic acid is used as a key intermediate in the synthesis of various organic compounds, particularly in the pharmaceutical and chemical industries. Its unique structure and reactivity make it a valuable building block for the development of new molecules with potential applications in these fields.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,4,5-Trimethylbenzoic acid is used as a starting material for the production of various drugs and drug candidates. Its versatile chemical properties allow for the creation of a wide range of therapeutic agents, including those with potential applications in treating various diseases and medical conditions.
Used in Dye and Pigment Industry:
2,4,5-Trimethylbenzoic acid is also utilized in the dye and pigment industry as a precursor for the synthesis of various organic dyes and pigments. Its chemical structure contributes to the development of colorants with specific properties, such as color intensity, stability, and resistance to fading.
Used in Material Science:
In the field of material science, 2,4,5-Trimethylbenzoic acid can be employed in the development of novel materials with specific properties, such as improved thermal stability, mechanical strength, or chemical resistance. Its unique structure and reactivity make it a promising candidate for the creation of advanced materials with potential applications in various industries.

InChI:InChI=1/C10H12O2/c1-6-4-8(3)9(10(11)12)5-7(6)2/h4-5H,1-3H3,(H,11,12)

Upstream product

• 95-93-2 1,2,4,5-tetramethylbenzene 
• 2040-07-5 2,4,5-trimethylacetophenone 
• 321132-14-3 (2,4,5-trimethyl-phenyl)-acetone 
• 124-38-9 carbon dioxide 
• 5469-19-2 1-bromo-2,4,5-trimethylbenzene 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 137-17-7 2,4,5-trimethylaniline 
• 141-53-7 sodium formate 
• 109-72-8 n-butyllithium 
• 1239951-53-1 2,4,5-trimethylcyclohexa-1,4-dienecarboxylic acid 
• 590-93-2 2-Butynoic acid 
• 513-81-5 2,3-dimethyl-buta-1,3-diene 
• 110-05-4 di-tert-butyl peroxide 

Downstream Products

• 89-05-4 1,2,4,5-benzenetetracarboxylic acid 
• 6051-66-7 2,5-dimethylterephthalic acid 
• 2790-09-2 4,6-dimethylisophthalic acid 
• 34824-32-3 2,4,6-trimethylbenzoyl chloride 
• 15249-96-4 2,4,5-trimethyl-cyclohexanecarboxylic acid 
• 4380-67-0 2,4,5-trimethylbenzamide 
• 58260-83-6 2,4,5-trimethylbenzonitrile 
• 94820-32-3 N-benzyl-2,4,5-trimethylbenzamide 
• 92492-87-0 2,4,5-trimethyl-benzoic acid-(2-dimethylamino-ethylamide) 
• 216658-21-8 2-[2-[3-Methylphenyl]ethyl]-4,5-dimethylbenzoic acid 
• 51664-96-1 2,4,5-trimethylbenzoic acid methyl ester 
• 34824-33-4 9-(2,4,5-Trimethyl-benzoyl)-phenanthren 
• 46725-45-5 dimethyl 4,6-dimethylbenzene-1,3-dicarboxylate 

Relevant academic research and scientific papers

2,4,5-trimethylbenzoic acid

The X-ray structure of the title compound, C10H12O2, has been determined. The carboxyl and its o-methyl group display typical evasive in-plane splaying away from each other. The carboxyl is coplanar with the benzene ring a

Preparation method for o-tolylacetic acid aryl formic acid derivative

The invention discloses a preparation method for an o-tolylacetic acid aryl formic acid derivative. According to the method, new C-C bonds can be formed, the organic o-tolylacetic acid aryl formic acid derivative is obtained, the good functional group tolerance is achieved, and the o-tolylacetic acid aryl formic acid derivative which cannot be easily obtained by adopting other methods can be synthesized; according to the method, adopted raw materials are easy to obtain, the yield is high, the reaction conditions are mild, the substrate range is wide, and after-treatment is simple and green.

Palladium-Catalyzed ortho-C-H Methylation of Benzoic Acids

A palladium-catalyzed methylation of C-H bonds of benzoic acids with di-tert-butyl peroxide as the methylating reagent under an external oxidant and ligand-free conditions has been achieved. The reaction is found to be directed by a weakly coordinating carboxyl group, offering a facile route for the synthesis of highly functionalized ortho-methyl benzoic acids.

Dehydro-aromatization of cyclohexene-carboxylic acids by sulfuric acid: Critical route for bio-based terephthalic acid synthesis

A novel dehydro-aromatization reaction under mild reaction conditions was successfully developed using sulfuric acid as a cost-effective and efficient oxidant. This reaction simplified the synthesis of terephthalic acid (TA, an important aromatic monomer precursor) from biomass-derived isoprene and acrylic acid.

Remarkable effect of PEG-1000-based dicationic ionic liquid for N-Hydroxyphthalimide-catalyzed aerobic selective oxidation of alkylaromatics

PEG 1000-based functional dicationic acidic ionic liquid (PEG 1000-DAIL) was used for the first time as the reaction solvent for the N-Hydroxyphthalimide (NHPI)-cobalt acetate(Co(OAc)2) catalyzed aerobic oxidations of alkylaromatics to the corresponding acids. It enhanced the efficient catalytic ability of NHPI: 99.9 % conversion of toluene with 99.5 % selectivity for benzoic acid could be obtained at 80 °C in 10 h and ethylbenzene was selectively oxidized to benzoic acid. Several alkylaromatics were efficiently oxidized to their corresponding acids under mild conditions. For substituted toluene, the conversions of substrates and the selectivity of products was affected by the position and kind of substituted groups, respectively. Both the catalyst and PEG1000-DAIL could be reused at least eight times without significantly decreasing the catalytic activity.

PROCESS FOR PRODUCING AROMATIC POLYCARBOXYLIC ACID

A process for producing an aromatic polycarboxylic acid in which all alkyl groups are converted into carboxyl groups in a high yield by decreasing a residual amount of an intermediate product is provided. The process comprises oxygen-oxidizing an aromatic compound having a plurality of alkyl groups (e.g., durene) in the presence of a catalyst containing a cyclic imino unit having an N—OR group (wherein R represents a hydrogen atom or a protecting group for a hydroxyl group) and a transition metal co-catalyst (e.g., a cobalt compound, a manganese compound, and a zirconium compound) under heating in a lower-temperature zone and a higher-temperature zone to produce an aromatic polycarboxylic acid in which a plurality of alkyl groups are oxidized into carboxyl groups. In an initial stage of the reaction, the reaction may be conducted in a first lower-temperature zone (a reaction temperature of 60 to 120° C. and a second lower-temperature zone (an intermediate temperature zone) (a reaction temperature of 100 to 140° C.); and then, in a latter stage of the reaction, the reaction may be conducted in a higher-temperature zone (a reaction temperature of 110 to 150° C.).

Mild and efficient boronic acid catalysis of Diels-Alder cycloadditions to 2-alkynoic acids

The concept of boronic acid catalysis (BAC) for the activation of unsaturated carboxylic acids is applied to the Diels-Alder cycloaddition between 2-alkynoic acids as dienophiles and various dienes. These [4+2] cycloadditions produce cyclohexadienyl carboxylic acids, which can be oxidized in situ to produce polysubstituted aromatic carboxylic acids. The boronic acid catalyst is suspected to provide activation by a LUMO-lowering effect of the unsaturated carboxylic acid likely via a covalent, monoacylated hemiboronic ester intermediate.

A free radical process for oxidation of hydrocarbons promoted by nonmetal xanthone and tetramethylammonium chloride under mild conditions

A nonmetal catalytic system consisting of N-hydroxyphthalimide, xanthone, and tetramethylammonium chloride was developed. A wide range of hydrocarbons could be oxidized efficiently with dioxygen under mild conditions. In the presence of xanthone and tetramethylammonium chloride, catalytic activity of N-hydroxyphthalimide was greatly improved, and selectivity for alkyl hydroperoxide was remarkably decreased.

INHIBITORS OF STEAROYL-COA DESATURASE

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.

BISMUTH MEDIATED OXIDATIONS

The invention relates to a process for the oxidation of a substrate comprising a benzylic alkyl moiety, said process comprising incubating the substrate with a bismuth complex comprising bismuth and a ligand and a stoichiometric source of oxygen.