5167-18-0

Basic information

• Product Name: 1,7-DIHYDRO-2-METHYL-6-PURINONE
• Synonyms: 6-HYDROXY-2-METHYLPURINE;1,7-DIHYDRO-2-METHYL-6-PURINONE;2-METHYLHYPOXANTHINE;6H-Purin-6-one, 1,7-dihydro-2-methyl-;6H-Purin-6-one, 1,7-dihydro-2-methyl- (9CI);1,7-Dihydro-2-Methyl-6H-Purin-6-One;1,7-Dihydro-2-methyl-6-purinone 2-Methylhypoxanthine;2-methyl-1,7-dihydro-purin-6-one
• CAS NO: 5167-18-0
• Molecular Formula: C6H6N4O
• Molecular Weight: 150.14
• Product Categories: PYRIMIDINE;Heterocycles
• Mol File: 5167-18-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 484.3°Cat760mmHg
• Flash Point: 246.7°C
• Appearance: /
• Density: 1.72g/cm³
• Refractive Index: 1.82
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1,7-DIHYDRO-2-METHYL-6-PURINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,7-DIHYDRO-2-METHYL-6-PURINONE(5167-18-0)
• EPA Substance Registry System: 1,7-DIHYDRO-2-METHYL-6-PURINONE(5167-18-0)

Safety Data

• Hazardous Substances Data: 5167-18-0(Hazardous Substances Data)

Usage

General Description

1,7-Dihydro-2-methyl-6-purinone is a chemical compound that belongs to the class of purine derivatives. It is a synthetic analogue of the naturally occurring purine base, adenine. 1,7-DIHYDRO-2-METHYL-6-PURINONE has been studied for its potential biological and pharmacological activities. It has been found to have anti-inflammatory and analgesic properties, making it a potential candidate for the development of new drugs for the treatment of inflammatory and pain-related conditions. Additionally, 1,7-dihydro-2-methyl-6-purinone has also been investigated for its potential use in the field of materials science for the development of novel polymers and materials with specific properties. Overall, this compound holds promise for various applications in the fields of medicine and materials science.

InChI:InChI=1/C6H6N4O/c1-3-9-5-4(6(11)10-3)7-2-8-5/h2H,1H3,(H2,7,8,9,10,11)

Upstream product

• 5442-02-4 5,6-diamino-2-methylpyrimidin-4(3H)-one sulfate 
• 77287-34-4 formamide 
• 1445-08-5 2-methyl-6-aminopurine 
• 45741-61-5 5,6-diamino-2-methylpyrimidin-4(3H)-one 
• 64-18-6 formic acid 
• 98011-06-4 5-Acetamido-4-amino-2-methylpyrimidine-6-(1H)-one 
• 91-22-5 quinoline 
• 117987-01-6 5-(methyl(ethoxy)methylene)-aminoimidazole-4-carboxamide 
• 72-40-2 5-amino-1H-imidazole-4-carboxamide monohydrochloride 
• 141-78-6 ethyl acetate 
• 91026-74-3 5-Acetamidoimidazole-4-carboxamide 

Downstream Products

• 100859-35-6 6-chloro-2-methyl-9H-purine 
• 38917-31-6 2-methyl-1,9-dihydro-purine-6-thione 
• 1008-47-5 2-methyl-6-methylsulfanyl-7(9)H-purine 
• 1026172-67-7 6-Chloro-9-(2-fluoro-benzyl)-2-methyl-9H-purine 
• 100859-35-6 6-chloro-2-methyl-7⁽⁹⁾H-purine 
• 38917-31-6 2-methyl-1,7-dihydro-purine-6-thione 

Relevant articles and documents

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against plasmodium falciparum dihydroorotate dehydrogenase

Plasmodium falciparum causes approximately 1 million deaths annually. However, increasing resistance imposes a continuous threat to existing drug therapies. We previously reported a number of potent and selective triazolopyrimidine-based inhibitors of P.

Synthetic studies directed towards agelasine analogs - Synthesis, tautomerism, and alkylation of 2-substituted N-methoxy-9-methyl-9H-purin-6- amines

N-Methoxy-9-methyl-9H-purin-6-amines, carrying various substituents in the 2 positions, were synthesized by the N-methylation of known 6-chloropurines, followed by a displacement of the chlorine. Great variations in the amino/imino tautomer ratio among the compounds studied were observed. The tautomers were identified by NMR methods. Treatment of N-methoxy-9-methyl-9H-purin-6-amines carrying alkyl, alkoxy, or amino substituents in the 2 position with benzyl bromide resulted in a mixture of N-7- and N6-benzylated compounds with the former as the major products. N-Methoxy-9-methyl-9H-purin-6-amines with strongly electronegative substituents at C-2 hardly reacted at all under the same set of reaction conditions. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

6-substituted purinyl piperazine derivatives

6-substituted purinyl piperazine derivatives and a method of synthesis for the derivatives are described. The 6-substituted purinyl piperazine derivatives are useful as cardiotonic agents and antiarrhythmic agents.