5172-97-4

Usage

Chemical class

DBFPEA belongs to the class of amphetamines, which are a group of psychoactive drugs that stimulate the central nervous system.

Structural composition

DBFPEA is composed of a dibenzo[b,d]furan ring system and a phenylethylamine moiety.

Psychoactive properties

DBFPEA has been identified as a potential psychoactive substance with stimulant effects.

Pharmacological properties

The specific pharmacological properties of DBFPEA are not well defined, indicating that more research is needed to understand its effects on the body.

Toxicological properties

The toxicological properties of DBFPEA are also not well defined, suggesting that further research is necessary to determine its potential risks and side effects.

Potential applications

DBFPEA may have potential implications in the field of neuropharmacology, which is the study of how drugs interact with the nervous system.

Research status

DBFPEA is a subject of further research to better understand its biological effects and potential applications in various fields, such as medicine and neuroscience.

Upstream product

• 100-01-6 4-nitro-aniline 
• 21506-11-6 1-nitro-4-[(trifluoromethyl)selanyl]benzene 
• 75264-92-5 tetramethylammonium trifluoromethylselenate⁽⁰⁾ 
• 540-37-4 p-aminoiodobenzene 
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• 62-53-3 aniline 

Downstream Products

• 27142-94-5 (4-Trifluoromethylselanyl-phenyl)-carbamic acid ethyl ester 
• 27142-91-2 Dimethyl-[4-(4-trifluoromethylselanyl-phenylazo)-phenyl]-amine 
• 27142-95-6 (4-Trifluoromethylselanyl-phenyl)-carbamic acid benzyl ester 
• 21506-12-7 (4-Trifluoracetylamino-phenyl)-trifluormethyl-selenid 
• 21506-19-4 Dichlor-(4-trifluoracetylamino-phenyl)-trifluormethyl-selen 
• 21506-25-2 (4-Trifluoracetylamino-phenyl)-trifluormethyl-selenoxid 
• 21514-23-8 (4-Acetylamino-phenyl)-trifluormethyl-selenon 
• 21506-18-3 Dichlor-<4-nitro-phenyl>-trifluormethyl-selenid 
• 21506-14-9 <4-Brom-phenyl>-dichlor-trifluormethyl-selen 
• 21506-21-8 <4-Brom-phenyl>-trifluormethyl-selenoxid 
• 21506-24-1 <4-Nitro-phenyl>-trifluormethyl-selenoxid 
• 21506-29-6 <4-Brom-phenyl>-trifluormethyl-selenon 
• 21506-09-2 1-bromo-4-[(trifluoromethyl)selanyl]benzene 
• 21506-11-6 1-nitro-4-[(trifluoromethyl)selanyl]benzene 

Relevant academic research and scientific papers

Chalcogen OCF3 Isosteres Modulate Drug Properties without Introducing Inherent Liabilities

The synthesis of SCF3 as well as SeCF3 isosteres of two OCF3-containing drugs was achieved through visible light and copper-catalyzed processes. Herein, we show that chalcogen replacement modulates physicochemical and ADME properties without introducing intrinsic liabilities. The SCF3 and SeCF3 groups are more lipophilic than their oxygen counterpart; however, microsomal stability is unchanged, indicating that these molecular changes may be beneficial for in vivo half-life. Enabled by modern synthetic methods, we present the chalcogen-CF3 groups as potential key players for future fluorinated pharmaceuticals.

Nickel-Catalyzed Trifluoromethylselenolation of Aryl Halides Using the Readily Available [Me4N][SeCF3] Salt

A convenient and efficient method for the construction of aryl trifluoromethyl selenoethers from the corresponding aryl halides in the presence of Ni(COD)2 and an appropriate ligand is reported. Various aryl iodides, bromides, and chlorides were smoothly converted in this reaction by simply varying the ligand, which afforded aryl and heteroaryl trifluoromethyl selenoethers in good to almost quantitative yields. The reaction was also applicable to the synthesis of druglike molecules. This work is the first report for trifluoromethylselenolation of aryl chlorides. Advantages of the present Ni-catalyzed approach include mild reaction conditions, good functional group tolerance, inexpensive reagents, easy operation, and no use of additional additives. This protocol allows for a straightforward and reliable access to trifluoromethyl selenides that are latent screening candidates for new pharmaceuticals and agrochemicals.

Highly Efficient C-SeCF3 Coupling of Aryl Iodides Enabled by an Air-Stable Dinuclear PdI Catalyst

Building on our recent disclosure of catalysis at dinuclear PdI sites, we herein report the application of this concept to the realization of the first catalytic method to convert aryl iodides into the corresponding ArSeCF3 compounds. Highly efficient C-SeCF3 coupling of a range of aryl iodides was achieved, enabled by an air-, moisture-, and thermally stable dinuclear PdI catalyst. The novel SeCF3-bridged dinuclear PdI complex 3 was isolated, studied for its catalytic competence and shown to be recoverable. Experimental and computational data are presented in support of dinuclear PdI catalysis.