5173-02-4Relevant articles and documents
Borazine-CF3? Adducts for Rapid, Room Temperature, and Broad Scope Trifluoromethylation
Geri, Jacob B.,Wade Wolfe, Michael M.,Szymczak, Nathaniel K.
supporting information, p. 1381 - 1385 (2018/01/15)
A fluoroform-derived borazine CF3? transfer reagent is used to effect rapid nucleophilic reactions in the absence of additives, within minutes at 25 °C. Inorganic electrophiles spanning seven groups of the periodic table can be trifluoromethylated in high yield, including transition metals used for catalytic trifluoromethylation. Organic electrophiles included (hetero)arenes, enabling C?H and C?X trifluoromethylation reactions. Mechanistic analysis supports a dissociative mechanism for CF3? transfer, and cation modification afforded a reagent with enhanced stability.
Electrophilic Trifluoromethyl- and Fluoroalkylselenolation of Organometallic Reagents
Glenadel, Quentin,Ismalaj, Ermal,Billard, Thierry
supporting information, p. 530 - 533 (2017/02/05)
Fluoroalkylseleno groups are emerging groups that still suffer from a lack of efficient methods for introduction onto organic molecules. Herein, we describe an efficient method to perform reactions between in situ formed fluoroalkaneselenyl chlorides and organometallic reagents. With this strategy, various fluoroalkylselenolated molecules were easily obtained. Furthermore, the Hansch parameter of the CF3Se group was determined for the first time.
S-Trifluoromethylation of Thiols by Hypervalent Iodine Reagents: A Joint Experimental and Computational Study
Sala, Oliver,Santschi, Nico,Jungen, Stefan,Lüthi, Hans Peter,Iannuzzi, Marcella,Hauser, Nicole,Togni, Antonio
supporting information, p. 1704 - 1713 (2016/02/20)
The radical trifluoromethylation of thiophenol in condensed phase applying reagent 1 (3,3-dimethyl-1-(trifluoromethyl)-1λ3,2-benziodoxol) has been examined by both theoretical and experimental methodologies. On the basis of ab initio molecular