5174-84-5Relevant academic research and scientific papers
Synthesis of 1,8-naphthyridines from 2-aminonicotinaldehydes and terminal alkynes
Li, Binbin,Nguyen, Steven,Huang, Jianjun,Wang, Gaigai,Wei, Huiping,Pereshivko, Olga P.,Peshkov, Vsevolod A.
, p. 1958 - 1962 (2016)
A copper(II) triflate-catalyzed diethylamine-assisted protocol for the reaction of 2-aminonicotinaldehydes and terminal alkynes leading to 1,8-naphthyridines is described. The overall process presumably involves a copper(II) triflate-catalyzed hydroaminat
A flexible synthesis of naphthyridine derivatives through diazotization, triflation, and Suzuki reaction
Shireen Mohammed, Maher Khalid
, p. 21 - 25 (2021/06/12)
A facile and suitable method for the synthesis of different 1,8-Naphthyridine derivatives is depicted. The procedure is based on the diazotization and triflation reactions of commercially available 1,8-naphthyridine-2-amines followed by cross-coupling with aromatic and heteroaromatic boronic acids through Suzuki reaction. These processes reserved the required yields in high percentage. All synthesized compounds were identified by spectral data.
Hydrogen-Transfer-Mediated α-Functionalization of 1,8-Naphthyridines by a Strategy Overcoming the Over-Hydrogenation Barrier
Chen, Xiu-Wen,Zhao, He,Chen, Chun-Lian,Jiang, Huan-Feng,Zhang, Min
supporting information, p. 14232 - 14236 (2017/10/31)
A general catalytic hydrogen transfer-mediated α-functionalization of 1,8-naphthyridines is reported for the first time that benefits from a hydrogen transfer-mediated activation mode for non-activated pyridyl cores. The pyridyl α-site selectively couples with the C8-site of various tetrahydroquinolines (THQs) to afford novel α-functionalized tetrahydro 1,8-naphthyridines, a class of synthetically useful building blocks and potential candidates for the discovery of therapeutic and bio-active products. The utilization of THQs as inactive hydrogen donors (HDs) appears to be a key strategy to overcome the over-hydrogenation barrier and address the chemoselectivity issue. The developed chemistry features operational simplicity, readily available catalyst and good functional group tolerance, and offers a significant basis for further development of new protocols to directly transform or functionalize inert N-heterocycles.
