51769-91-6

Upstream product

• 123-75-1 pyrrolidine 
• 2644-96-4 2-(4-nitrobenzamido)acetic acid methyl ester 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 51770-31-1 2,2,2-trifluoro-1-[2-(4-nitro-phenyl)-5-pyrrolidin-1-yl-oxazol-4-yl]-ethanone 
• 51770-33-3 2-(4-nitro-phenyl)-5-pyrrolidin-1-yl-oxazole-4-carboxylic acid 
• 51769-99-4 2-(4-nitro-phenyl)-5-pyrrolidin-1-yl-oxazole 

Relevant academic research and scientific papers

Substituent effect on acidity of substituted 2-(4-nitrobenzoylamino)alkanamidesin methanol-dimethyl sulfoxide mixtures

The dissociation constants of substituted 2-(4-nitrobenzoylamino)alkanamides, N-[2-(4-nitrobenzoylamino)aikanoyl]pyrrolidines, and N-alkyl-4-nitrobenzamides have been measured spectrophotometrically in 60 and 80% v/v DMSO. The pKA values of these N-acids are discussed from the point of view of substituents at the acetamide a-carbon atom.

Dissociation of amides in strongly basic medium of sodium methoxide in dimethyl sulfoxide-methanol mixtures

The dissociation constants of eleven amides have been measured in methanol and its mixtures with dimethyl sulfoxide (10 to 80% v/v) using sodium methoxide as the base. The experimental dissociation constants have been used to construct the H- acidity function as a function of methoxide concentration and composition of the DMSO-MeOH mixture as well as function of methoxide concentration in methanol. Moreover, with the help of construction of acidity function, the functions have been devised for constant sodium methoxide concentrations (0.025, 0.1, and 0.2 mol 1-1) and changing composition of the DMSO-MeOH mixture.