51781-13-6

Basic information

• Product Name: 2(1H)-Quinolinone, 5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro-
• CAS NO: 51781-13-6
• Molecular Formula: C12H14ClNO3
• Molecular Weight: 255.701
• Mol File: 51781-13-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2(1H)-Quinolinone, 5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinolinone, 5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro-(51781-13-6)
• EPA Substance Registry System: 2(1H)-Quinolinone, 5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro-(51781-13-6)

Safety Data

• Hazardous Substances Data: 51781-13-6(Hazardous Substances Data)

Usage

General Description

2(1H)-Quinolinone, 5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro- is a chemical compound with the molecular formula C13H15ClNO3. It is a quinolinone derivative with a 3-chloro-2-hydroxypropoxy side chain attached to the 5-position. 2(1H)-Quinolinone, 5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro- is used in the field of medicinal chemistry and drug research, where it has been studied for its potential biological activities. It has been investigated for its anti-inflammatory, anti-cancer, and anti-viral properties, as well as its potential as a therapeutic agent for neurological disorders. Its unique structure and potential biological activities make it a subject of interest for further research and development of pharmaceutical applications.

Upstream product

• 30389-33-4 5-hydroxycarbostyril 
• 106-89-8 epichlorohydrin 

Downstream Products

• 51781-21-6 carteolol hydrochloride 

Relevant articles and documents

Improved Delivery through Biological Membranes. 26. Design, Synthesis, and Pharmacological Activity of a Novel Chemical Delivery System for β-Adrenegic Blocking Agents

Novel ketoxime analogues of known β-blockers (propranolol, timolol, carteolol) and tested as potential site-specific chemical delivery systems.It was assumed that a hydrolysis-reduction sequence could produce the active β-blockers in the iris-ciliary body.It was found that some of these bioprecursors are remarcable active in reducing intraocular pressure in rabbits.The ketoxime derivative of propranolol is more effective and much less irritant than its parent β-blocker.While the ketoximes also displayed activity on isoprenaline-induced tachycardia after iv administration, they were void of activity when given orally.Propranolol was found for a prolonged time and in significant concentrations in the rabbit's eye following topical administration of its ketoxime precursor; however, the inactive ketoximes apparently were not converted to the corresponding β-blockers in the eye.A correlation was found between the physicochemical properties of the ketoximes and their conversion to the amino alcohol and thus their subsequent activity.The results suggest that at least some of the ketoxime precursors could have a use as antiglaucoma agents without systemic side effects.