2(1H)-Quinolinone, 5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro-

Base Information

• Chemical Name: 2(1H)-Quinolinone, 5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro-
• CAS No.: 51781-13-6
• Molecular Formula: C12H14ClNO3
• Molecular Weight: 255.701
• UNII: YJ3B2VF7CQ
• Mol file: 51781-13-6.mol

Synonyms:51781-13-6;2(1H)-Quinolinone, 5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro-;YJ3B2VF7CQ;Carteolol HCl EP Impurity D;UNII-YJ3B2VF7CQ;Carteolol hydrochloride impurity D [EP];5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro-1H-quinolin-2-one;5-(3-Chloro-2-hydroxypropoxy)-3,4-dihydro-2(1H)-quinolinone;5-((2RS)-3-Chloro-2-hydroxypropoxy)-3,4-dihydroquinolin-2(1H)-one;SCHEMBL9336314;CARTEOLOL HYDROCHLORIDE IMPURITY D [EP IMPURITY];5-(3-Chloro-2-hydroxypropoxy)-3,4-dihydroquinolin-2(1H)-one

Chemical Property of 2(1H)-Quinolinone, 5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro-

Chemical Property:

• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 255.0662210
• Heavy Atom Count: 17
• Complexity: 275

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=O)NC2=C1C(=CC=C2)OCC(CCl)O

Technology Process of 2(1H)-Quinolinone, 5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro-

There total 2 articles about 2(1H)-Quinolinone, 5-(3-chloro-2-hydroxypropoxy)-3,4-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-hydroxycarbostyril (30389-33-4) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 3-(1-naphthyloxy)-1,2-epoxypropane (2461-42-9) + 5-(3-chloro-2-hydroxypropoxy)-3,4-dihydrocarbostyril (51781-13-6)

Guidance literature:

With morpholine; hydrogenchloride; Yield given. Multistep reaction; 1.) reflux, 16 h, 2.) 15 min;

DOI:10.1021/jm00396a015

Reference yield:

5-hydroxycarbostyril (30389-33-4) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 5-(2,3-epoxypropoxy)-3,4-dihydro-2 (1H)-quinolone (51781-14-7) + 5-(3-chloro-2-hydroxypropoxy)-3,4-dihydrocarbostyril (51781-13-6)

Guidance literature:

In ethanol;

Reference yield:

5-(3-chloro-2-hydroxypropoxy)-3,4-dihydrocarbostyril (51781-13-6) + tert-butylamine (75-64-9) → methanolic hydrogen chloride + carteolol hydrochloride (51781-21-6)

Guidance literature:

In 1,4-dioxane;

upstream raw materials:

5-hydroxycarbostyril

epichlorohydrin

Downstream raw materials:

carteolol hydrochloride