517867-34-4Relevant academic research and scientific papers
Flexible routes to thiophenes
Jullien, Helene,Quiclet-Sire, Beatrice,Tetart, Thomas,Zard, Samir Z.
supporting information, p. 302 - 305 (2014/01/23)
Three convergent routes to thiophenes are described, hinging on the radical addition of α-xanthyl ketones to ethyl vinyl sulfide or to vinyl pivalate. The latter route ultimately proved to be the most versatile and efficient (61-94%).
Method of preparing benzazepines and derivatives thereof
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Page/Page column 8, (2008/06/13)
The invention relates to a method of preparing benzazepine compounds having general formula (IA) consisting in reacting at least one compound having general formula (IIA) with an olefin, the compound thus obtained then being cyclised such as to produce tetralone, followed by the oxime derivative of same, which, by transformation by a Beckmann rearrangement, gives rise to the desired compounds.
A flexible approach for the preparation of substituted benzazepines: Application to the synthesis of tolvaptan
Cordero-Vargas, Alejandro,Quiclet-Sire, Beatrice,Zard, Samir Z.
, p. 6165 - 6173 (2007/10/03)
A practical preparation of benzazepine derivatives using a series of radical and ionic reactions is reported. This approach was applied to the synthesis of tolvaptan, a very promising vasopressin V2 receptor antagonist currently in clinical trials.
A practical variation on the Paal-Knorr pyrrole synthesis
Quiclet-Sire, Béatrice,Quintero, Leticia,Sanchez-Jimenez, Graciela,Zard, Samir Z.
, p. 75 - 78 (2007/10/03)
The radical addition of α-xanthyl ketones to vinyl pivalate gives adducts that are synthetic equivalents of 1,4-ketoaldehydes; treatment with ammonia or primary amines leads to the corresponding pyrroles in high yield.
A new, unexpected synthesis of 1,3-dithietanones
Quiclet-Sire, Beatrice,Sanchez-Jimenez, Graciela,Zard, Samir Z.
, p. 1408 - 1409 (2007/10/03)
Treatment of a geminal pivaloxy xanthate, prepared by an intermolecular radical addition of a xanthate to vinyl pivalate, gives a 1,3-dithietanone, a little known class of compounds.
