51794-05-9Relevant academic research and scientific papers
ALPHA-CINNAMIDE COMPOUNDS AND COMPOSITIONS AS HDAC8 INHIBITORS
-
Paragraph 0980; 0981, (2016/10/04)
The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.
N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: Design, synthesis, SAR studies, and in vivo antitumor activity
Wang, Haishan,Yu, Niefang,Song, Hongyan,Chen, Dizhong,Zou, Yong,Deng, Weiping,Lye, Pek Ling,Chang, Joyce,Ng, Melvin,Sun, Eric T.,Sangthongpitag, Kanda,Wang, Xukun,Wu, Xiaofeng,Khng, Hwee Hoon,Fang, Lijuan,Goh, Siok Kun,Ong, Wai Chung,Bonday, Zahid,Stuenkel, Walter,Poulsen, Anders,Entzeroth, Michael
scheme or table, p. 1403 - 1408 (2009/10/15)
A series of N-hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides were designed and synthesized as novel HDAC inhibitors. General SAR has been established for the substituents at positions 1 and 2, as well as the importance of the ethylene group an
INDOLE DERIVATIVES AS ANTIVIRAL AGENTS
-
Page/Page column 28-29, (2010/10/20)
The present invention relates to indole compounds of the formula (I): wherein R1, R2, R3, R4, A, E and X are as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections.
