877065-30-0

Basic information

• Product Name: (E)-Methyl 3-(4-chloro-3-nitrophenyl)acrylate
• Synonyms: (E)-Methyl 3-(4-chloro-3-nitrophenyl)acrylate;Methyl (E)-3-(4-chloro-3-nitrophenyl)acrylate, Methyl (2E)-3-(4-chloro-3-nitrophenyl)prop-2-enoate;Methyl trans-4-chloro-3-nitrocinnamate;Methyl 3-(4-chloro-3-nitrophenyl)acrylate;methyl (E)-3-(4-chloro-3-nitrophenyl)acrylate;3-(4-Chloro-3-nitro-phenyl)-acrylic acid methyl ester
• CAS NO: 877065-30-0
• Molecular Formula: C₁₀H₈ClNO₄
• Molecular Weight: 241.62782
• Mol File: 877065-30-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol (Slightly)
• CAS DataBase Reference: (E)-Methyl 3-(4-chloro-3-nitrophenyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-Methyl 3-(4-chloro-3-nitrophenyl)acrylate(877065-30-0)
• EPA Substance Registry System: (E)-Methyl 3-(4-chloro-3-nitrophenyl)acrylate(877065-30-0)

Safety Data

• Hazardous Substances Data: 877065-30-0(Hazardous Substances Data)

Usage

General Description

(E)-Methyl 3-(4-chloro-3-nitrophenyl)acrylate is a chemical compound that is commonly used in the field of organic synthesis and pharmaceutical research. It is a ester derivative of acrylic acid and is characterized by its distinct yellow color. (E)-Methyl 3-(4-chloro-3-nitrophenyl)acrylate is known for its reactive nature and is often utilized in the production of various pharmaceutical intermediates. Additionally, it serves as a key building block in the synthesis of complex organic molecules and is used in the preparation of drugs and agrochemicals. The presence of the chloro and nitro functional groups in its molecular structure imparts unique and versatile chemical reactivity, making it a valuable tool in chemical synthesis. Overall, (E)-Methyl 3-(4-chloro-3-nitrophenyl)acrylate plays a crucial role in the development of new pharmaceuticals and materials.

Upstream product

• 20797-48-2 (E)-4-chloro-3-nitrocinnamic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 

Downstream Products

• 51794-05-9 (E)-methyl 3-(4-amino-3-nitrophenyl)acrylate 
• 929018-83-7 (E)-3-[4-(2-aminoethylamino)-3-nitrophenyl]acrylic acid methyl ester 
• 929018-74-6 (E)-3-[4-(2-ethylaminoethylamino)-3-nitrophenyl]acrylic acid methyl ester 
• 1312574-49-4 (E)-3-[4-(2-aminoethylamino)-3-nitrophenyl]acrylic acid methyl ester hydrochloride 
• 1312574-54-1 C₁₈H₂₇N₃O₄ 

Relevant articles and documents

Minor structural modifications to Pracinostat produce big changes in its biological responses

A series of compounds similar to Pracinostat that contained benzimidazole ring and N-hydroxyacrylamide attached at 5- or 6-position were designed, synthesized, and evaluated as HDAC inhibitors. It was interesting to find that the corresponding derivative 1 with N-hydroxyacrylamide attached at 5-position was a potent HDAC inhibitor while the others at 6-position were not. This is the first time to demonstrate the position difference plays important role in the HDAC inhibitory activities of the cinnamic hydroxamates.

NEW CYCLOHEXYL AND QUINUCLIDINYL CARBAMATE DERIVATIVES HAVING BETA2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITY

The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: Design, synthesis, SAR studies, and in vivo antitumor activity

A series of N-hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides were designed and synthesized as novel HDAC inhibitors. General SAR has been established for the substituents at positions 1 and 2, as well as the importance of the ethylene group an