1-Boc-3-fluoropyrrolidine

Base Information

Chemical Name:1-Boc-3-fluoropyrrolidine
CAS No.:518063-52-0
Molecular Formula:C9H16FNO2
Molecular Weight:189.23
Hs Code.:
Mol file:518063-52-0.mol

Synonyms:tert-butyl 3-fluoropyrrolidine-1-carboxylate;3-Fluoro-1-pyrrolidinecarboxylic acid tert-butyl ester;N-tert-Butoxycarbonyl-3-fluoropyrrolidine

Suppliers and Price of 1-Boc-3-fluoropyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl3-fluoropyrrolidine-1-carboxylate 95+%
1g
$ 402.00

Chemenu
tert-butyl3-fluoropyrrolidine-1-carboxylate 95%
1g
$ 380.00

Alichem
tert-Butyl3-fluoropyrrolidine-1-carboxylate
1g
$ 347.68

Total 12 raw suppliers

Chemical Property of 1-Boc-3-fluoropyrrolidine

Chemical Property:

Boiling Point:230℃
Flash Point:93℃
PSA：29.54000
Density:1.08
LogP:1.90320
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-fluoropyrrolidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Boc-3-fluoropyrrolidine

There total 6 articles about 1-Boc-3-fluoropyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.8%

: 1-N-tert-butoxycarbonyl-3-trifluoromethanesulfonyloxypyrrolidine

: 518063-52-0
tert-butyl 3-fluoropyrrolidine-1-carboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; Inert atmosphere; Reflux;

Reference yield: 79.0%

: 103057-44-9,83220-73-9
N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine

: 518063-52-0
tert-butyl 3-fluoropyrrolidine-1-carboxylate

Guidance literature:: N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine; With pyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -10 - -5 ℃;

In dichloromethane; at 20 ℃; Further stages.;
DOI:10.1021/jo8015659

Reference yield: 75.0%

: 939793-16-5,569660-97-5
3-bromopyrrolidine-1-carboxylic acid tert-butyl ester

: 518063-52-0
tert-butyl 3-fluoropyrrolidine-1-carboxylate

Guidance literature:: With potassium phosphate; benzophenone; 1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)-2-trisilanol; N-fluorobis(benzenesulfon)imide; In water; acetonitrile; at 20 ℃; for 4h; Irradiation; Inert atmosphere;
DOI:10.1021/jacs.9b11434