518335-55-2

Upstream product

• 4885-02-3 Dichloromethyl methyl ether 
• 169775-23-9 5-bromo-3-methyl-1,2,4-trimethoxybenzene 
• 105103-87-5 5-bromo-2,4-dimethoxy-3-methylphenol 
• 383187-30-2 propionic acid 2,4-dimethoxy-3-methylphenyl ester 
• 518335-54-1 propionic acid 5-bromo-2,4-dimethoxy-3-methylphenyl ester 

Downstream Products

• 518335-57-4 (2R,4S,5R)-1-[(4R)-benzyl-2-oxo-oxazolidin-3-yl]-5-(2-bromo-3,5,6-trimethoxy-4-methylphenyl)-5-hydroxy-2,4-dimethylpentane-1,3-dione 
• 95306-76-6 2-bromo-3,5,6-trimethoxy-4-methylbenzaldehyde 

Relevant academic research and scientific papers

Stereocontrolled synthesis of C-arylglycosides applied to the south west fragment of the antibiotic kendomycin

A nine step synthesis of the southwest fragment 3 of the antibiotic kendomycin (1) is reported. The tetrahydropyran ring is prepared in a highly stereocontrolled and efficient sequence. The key step concerns an anti-aldol reaction using chiral ketone 10. C-Aryl glycoside 3 exhibits atropisomerism and the relative configuration around its tetrahydropyran ring was established by NOE experiments.