518357-51-2 Usage
Uses
3-MATIDA is a potent mGluR-1 antagonist.
Biological Activity
Potent metabotropic glutamate mGlu 1 receptor antagonist (IC 50 = 6.3 μ M at rat mGlu 1a ). Displays ≥ 40-fold selectivity over other receptors: mGlu 5 , mGlu 2 , mGlu 4a (IC 50 > 300 μ M), NMDA and AMPA (IC 50 = 250 μ M). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures in vitro . Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 518357-51-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,1,8,3,5 and 7 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 518357-51:
(8*5)+(7*1)+(6*8)+(5*3)+(4*5)+(3*7)+(2*5)+(1*1)=162
162 % 10 = 2
So 518357-51-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO4S/c1-3-2-4(7(10)11)14-6(3)5(9)8(12)13/h2,5H,9H2,1H3,(H,10,11)(H,12,13)
518357-51-2Relevant academic research and scientific papers
Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): Identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist
Costantino, Gabriele,Marinozzi, Maura,Camaioni, Emidio,Natalini, Benedetto,Sarichelou, Iran,Micheli, Fabrizio,Cavanni, Paolo,Faedo, Stefania,Noe, Christian,Moroni, Flavio,Pellicciari, Roberto
, p. 93 - 99 (2007/10/03)
The synthesis of the (+)- and (-)-isomers of 3-methyl-5-carboxy-thyen-2-yl- glycine (3-MATIDA), heterocyle isosters of carboxyphenylglycines (CPGs), a known class of competitive metabotropic glutamate receptors, was accomplished by a stereoselective Ugi condensation. The two isomers were tested as potential rat mGluR1 ligand and the (+) isomer was found to be a moderately potent antagonist, while the (-) one was inactive.
