391936-75-7Relevant academic research and scientific papers
Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): Identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist
Costantino, Gabriele,Marinozzi, Maura,Camaioni, Emidio,Natalini, Benedetto,Sarichelou, Iran,Micheli, Fabrizio,Cavanni, Paolo,Faedo, Stefania,Noe, Christian,Moroni, Flavio,Pellicciari, Roberto
, p. 93 - 99 (2004)
The synthesis of the (+)- and (-)-isomers of 3-methyl-5-carboxy-thyen-2-yl- glycine (3-MATIDA), heterocyle isosters of carboxyphenylglycines (CPGs), a known class of competitive metabotropic glutamate receptors, was accomplished by a stereoselective Ugi condensation. The two isomers were tested as potential rat mGluR1 ligand and the (+) isomer was found to be a moderately potent antagonist, while the (-) one was inactive.
