5185-54-6

Usage

Uses

Used in Pharmaceutical Applications:
2,6-DICHLORO-4-PHENYL-QUINAZOLINE is used as a potential anticancer agent, given its ability to target and inhibit the growth of cancer cells. Its unique structure allows it to interact with specific biological targets, making it a promising candidate for the development of new cancer therapies.
Additionally, 2,6-DICHLORO-4-PHENYL-QUINAZOLINE is used as a potential antimicrobial agent, leveraging its ability to combat microbial infections by disrupting essential cellular processes in bacteria and other microorganisms. This property positions it as a candidate for the development of new antimicrobial drugs to address the growing issue of antibiotic resistance.
Used in Organic Synthesis:
2,6-DICHLORO-4-PHENYL-QUINAZOLINE is used as a building block in organic synthesis for the creation of new compounds with diverse applications. Its unique structure and functional groups make it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. Researchers can exploit its reactivity and structural features to design and synthesize novel molecules with improved properties and functionalities.

InChI:InChI=1/C14H8Cl2N2/c15-10-6-7-12-11(8-10)13(18-14(16)17-12)9-4-2-1-3-5-9/h1-8H

Upstream product

• 4797-43-7 6-chloro-4-phenyl-2-quinazolinone 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 4797-43-7 6-chloro-4-phenylquinazolin-2-ol 

Downstream Products

• 57370-20-4 6-Chlor-2-hydrazino-4-phenyl-chinazolin 
• 100693-28-5 6-Chloro-2-(3,5-dimethyl-pyrazol-1-yl)-4-phenyl-quinazoline 
• 100672-14-8 2-(6-Chloro-4-phenyl-quinazolin-2-yl)-5-methyl-2,4-dihydro-pyrazol-3-one 
• 100672-17-1 6-Chloro-4-phenyl-2-(3,3,5-trimethyl-2,3-dihydro-pyrazol-1-yl)-quinazoline 
• 100672-19-3 5-Amino-2-(6-chloro-4-phenyl-quinazolin-2-yl)-1,2-dihydro-pyrazol-3-one 
• 100672-22-8 1-(6-Chloro-4-phenyl-quinazolin-2-yl)-4-phenyl-1H-pyrazol-3-ylamine 
• 67095-57-2 (6-chloro-4-phenyl-quinazolin-2-yl)-(2,2-dimethoxy-ethyl)-amine 
• 1026768-90-0 6-chloro-2-formamido-4-phenylquinazoline 
• 1026769-15-2 6-chloro-2-(2-hydroxyethylthio)-4-phenylquinazoline 
• 51483-21-7 6-chloro-4-phenylquinazoline-2-carbonitrile 
• 1026768-87-5 6-chloro-2-methoxyamino-4-phenylquinazoline 
• 1026768-88-6 6-chloro-2-ethoxycarbonylmethylamino-4-phenylquinazoline 
• 919955-17-2 6-chloro-2-furfurylamino-4-phenylquinazoline 
• 64820-61-7 7-chloro-5-phenyl-tetrazolo[1,5-a]quinazoline 

Relevant academic research and scientific papers

4-ARYLQUINAZOLINE DERIVATIVES AS INHIBITORS OF METHIONINE ADENOSYLTRANSFERASE 2A

The invention relates to certain derivatives of 4-arylquinazoline formula (I) which are inhibitors of methionine adenosyltransferase 2A (MAT2A). The invention also relates to pharmaceutical compositions comprising such compounds and methods of treating diseases that can be treated by inhibition of MAT2A such as cancer, including cancers characterized by reduced or no activity of methylthioadenosine phosphorylase (MTAP).

SUBSTANCE CAPABLE OF INHIBITING CYTOKININ SIGNALING

Disclosed are: a substance which has an activity of inhibiting the intracellular signaling from a plant-derived cytokinin receptor and which can control the growth or differentiation of a plant. Also, disclose is a method for searching for a chemical subs

Derivatives of 4-phenyl quinazoline active on the central nervous system

The present invention relates to novel derivatives of 4-phenyl quinazoline of general formula: STR1 in which R2 is H or halogen or R1 is a hydroxyamino derivative of type STR2 in which at least R3 or R4 comprise

Synthesis and Antiinflammatory Activity of 4-Aryl-2-(1'-pyrazolyl)quinazolines

4-Aryl-2-hydrazinoquinazolines (III) on condensation with acetylacetone, ethyl acetoacetate, mesityl oxide, ethyl cyanoacetate and α-formylphenylacetonitrile afford the corresponding 4-aryl-2-(1'-pyrazolyl)quinazolines (IV, V, VIII, XII and XVI).These com