51483-21-7

Upstream product

• 4797-43-7 6-chloro-4-phenylquinazolin-2-ol 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 773837-37-9 sodium cyanide 
• 5185-54-6 2-chloro-4-phenyl-6-chloroquinazoline 

Downstream Products

• 5958-08-7 6-chloro-4-phenylquinazoline-2-carboxylic acid 

Relevant academic research and scientific papers

4-ARYLQUINAZOLINE DERIVATIVES AS INHIBITORS OF METHIONINE ADENOSYLTRANSFERASE 2A

The invention relates to certain derivatives of 4-arylquinazoline formula (I) which are inhibitors of methionine adenosyltransferase 2A (MAT2A). The invention also relates to pharmaceutical compositions comprising such compounds and methods of treating diseases that can be treated by inhibition of MAT2A such as cancer, including cancers characterized by reduced or no activity of methylthioadenosine phosphorylase (MTAP).

A facile synthesis of N-arylcyanoformamidoximes, 4-aryl-3-cyano-1,2,4- oxadiazin-5(6H)-ones, 2-cyanoquinazolin-3-oxides, and 2-cyanoquinazolines via 5-arylimino-4-chloro-5H-1,2,3-dithiazoles

The reaction of 5-arylimino-4-chloro-5H-1,2,3-dithiazoles with hydroxylamine hydrochloride in pyridine at room temperature gave N- arylcyanoformamidoximes, which were utilized as starting materials for the synthesis of 4-alkyl- (or aryl)-2-cyanoquinazolines and 4-aryl-3-cyano-1,2,4- oxadiazin-5(6H)-ones.