51867-62-0

Basic information

• Product Name: 3-chloroformyl-7-methoxycoumarin
• Synonyms: 3-chloroformyl-7-methoxycoumarin
• CAS NO: 51867-62-0
• Molecular Formula: C₁₁H₇ClO₄
• Molecular Weight: 238.62
• Mol File: 51867-62-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 407.5°Cat760mmHg
• Flash Point: 182.9°C
• Appearance: /
• Density: 1.444g/cm³
• Vapor Pressure: 7.5E-07mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 3-chloroformyl-7-methoxycoumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloroformyl-7-methoxycoumarin(51867-62-0)
• EPA Substance Registry System: 3-chloroformyl-7-methoxycoumarin(51867-62-0)

Safety Data

• Hazardous Substances Data: 51867-62-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H7ClO4/c1-15-7-3-2-6-4-8(10(12)13)11(14)16-9(6)5-7/h2-5H,1H3

Upstream product

• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 6093-72-7 7-methoxycoumarin-3-carboxylic acid ethyl ester 
• 6093-71-6 7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethyl ester 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 20300-59-8 7-methoxycoumarin-3-carboxylic acid 

Downstream Products

• 51867-57-3 7-methoxy-3-(5-phenyl-[1,3,4]oxadiazol-2-yl)-chromen-2-one 
• 97632-73-0 (7-Methoxy-2-oxo-2H-chromen-3-yl)-carbamic acid benzyl ester 
• 97632-70-7 (7-Methoxy-2-oxo-2H-chromen-3-yl)-carbamic acid cyclohexyl ester 
• 97632-67-2 7-methoxycoumarin-3-carbonyl azide 
• 6093-72-7 7-methoxycoumarin-3-carboxylic acid ethyl ester 

Relevant articles and documents

Incorporation of a FRET pair within a phosphonate diester

Cell-cleavable protecting groups are an effective tactic for construction of biological probes because such compounds can improve problems with instability, solubility, and cellular uptake. Incorporation of fluorescent groups in the protecting groups may afford useful probes of cellular functions, especially for payloads containing phosphonates that would be highly charged if not protected, but little is known about the steric or electronic factors that impede release of the payload. In this report we present a strategy for the synthesis of a coumarin fluorophore and a 4-((4-(dimethylamino)phenyl)diazenyl)benzoic acid (DABCYL) ester chromophore incorporated as a FRET pair within a single phosphonate. Such compounds were designed to deliver a BTN3A1 ligand payload to its intracellular receptor. Both final products and some synthetic intermediates were evaluated for their ability to undergo metabolic activation in γδ T cell functional assays, and for their photophysical properties by spectrophotometry. One phosphonate bearing a DABCYL acyloxyester and a novel tyramine-linked coumarin fluorophore exhibited strong, rapid, and potent cellular activity for γδ T cell stimulation and also showed FRET interactions. This strategy demonstrates that bioactivatable phosphonates containing FRET pairs can be utilized to develop probes to monitor cellular uptake of otherwise charged payloads.

SULFONATE COMPOUND, PHOTOACID GENERATOR, AND RESIN COMPOSITION FOR PHOTOLITHOGRAPHY

Provided are: a non-ionic photoacid generator containing a sulfonate compound having a high photosensitivity to i lines, exhibiting excellent heat-resistance stability, and exhibiting excellent solubility in a hydrophobic material; and a resin composition

Synthesis and anticholinesterase activity of coumarin-3-carboxamides bearing tryptamine moiety

A number of N-(2-(1H-indol-3-yl)ethyl)-2-oxo-2H-chromene-3-carboxamides were synthesized and tested against AChE and BuChE. The in?vitro assessment of the synthesized compounds 4a-o revealed that most of them had significant activity toward AChE. The SAR study demonstrated that the introduction of benzyloxy moiety on the 7-position of coumarin scaffold can improve the anti-AChE activity. The best result was obtained with 7-(4-fluorobenzyl)oxy moiety in the case of compound 4o, displaying IC50value of 0.16?μM. Based on the docking study of AChE, the prototype compound 4o was laid across the active site and occupied both peripheral anionic site (PAS) and catalytic anionic site (CAS).