51874-01-2Relevant academic research and scientific papers
Iron-catalyzed dehydration of aldoximes to nitriles requiring neither other reagents nor nitrile media
Hyodo, Kengo,Kitagawa, Saki,Yamazaki, Masayuki,Uchida, Kingo
, p. 1348 - 1352 (2016)
The dehydration of aldoximes is an environmentally benign reaction affording the desired nitrile and water as a by-product. However, most of the reported catalytic dehydration reactions of aldoximes require a solvent containing nitrile to synthesize the corresponding nitrile compounds. Inspired by recent reports on the enzymatic synthesis under nitrile-free conditions, we here describe that a simple iron salt catalyzes the dehydration of aldoximes requiring neither other reagents nor nitrile media. Our method can be applied to the one-pot synthesis of nitiriles from aldehydes. Dehydration causes: The dehydration of aldoximes is an environmentally benign reaction affording the desired nitrile and water as a by-product. However, most of the reported catalytic dehydration reactions of aldoximes require a solvent containing nitrile to synthesize the corresponding nitrile compounds. Inspired by recent reports on the enzymatic synthesis under nitrile-free conditions, here a simple iron salt-catalyzed dehydration of aldoximes requiring neither other reagents nor nitrile media is reported.
