51903-93-6Relevant academic research and scientific papers
FGFR INHIBITOR AND APPLICATION THEREOF
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Paragraph 0105-0106, (2020/01/22)
An azatricyclic compound (as represented by formula I) which acts as an inhibitor of fibroblast growth factor receptors (FGFR), as well as a pharmaceutical composition thereof, a preparation method, and a use therefor in the treatment of FGFR-mediated diseases. The azatricyclic compound exerts an effect by means of participating in the regulation of a plurality of processes such as cell proliferation, apoptosis, migration, neovascularization, and the like. AA%%%Formula (I).
TERTIARY AMIDES AND METHOD OF USE
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Paragraph 00584; 00585, (2017/11/04)
Compunds of Formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation of lysophosphatidic acid receptor 1. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
STRUCTURAL STUDIES OF GLYCOPEPTIDE ANTIBIOTIC A35512B. IDENTIFICATION OF THE DIPHENYL ETHER-TYPE BIS(AMINO ACID).
Harris, Constance M.,Harris, Thomas M.
, p. 1661 - 1666 (2007/10/02)
A35512B is one of the components of the A35512 complex of glycopeptide antibiotics recently isolated from Streptomyces candidus.Hydrolysis of the aglycone with 6N HCl gave actinoidinic acid (6), and the previously reported Cl-containing diphenyl ether-type bis(phenylglycine) 2.Hydrolysis of the aglycone in 57percent HI gave 6, tris(amino acid) 5b arising from reduction of the β-OH groups of amino acid 5a, and amino acid 7, formed by dehalogenation of 2.Amino acids 2 and 7 were oxidatively degraded to bis(benzoates) 3d and 10.The structures of 3d and 10 were confirmed by independent syntheses.Amino acid 2 is assigned structure 2d rather than the previously proposed structures 2a or 2b.The absolute configuration of 2d was determined as R for the para-hydroxylated ring and S for the meta-hydroxylated ring.
