519189-06-1

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 161564-09-6 (3R,5R)-1-benzyl-5-[(tert-butyldimethylsilyl)oxy]-piperidin-3-ol 
• 154343-02-9 (2S,4R)-4-{[1-(tert-butyl)-1,1-dimethylsilyl]-oxy}-1-benzyl-2-hydroxy-methyl-pyrrolidin 
• 51-35-4 4R-4-hydroxyproline 
• 154429-40-0 (2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid methyl ester 
• 114676-48-1 (2S,4R)-1-benzyl-4-hydroxyproline methyl ester 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 

Relevant academic research and scientific papers

A new nitrone from C2 symmetric piperidine for the synthesis of hydroxylated indolizidinone

The oxidation of a C2 symmetric piperidine, obtained through a ring enlargement process of the enantiopure protected (4R)-hydroxy-(2S)-hydroxymethyl pyrrolidine, is reported. Oxidation with C-phenyl-N-phenylsulfonyloxaziridine afforded the corr

Enantioselective diethylzinc addition to aromatic and aliphatic aldehydes using (3R,5R)-dihydroxypiperidine derivatives catalyst

A series of chiral (3R,5R)-dihydroxypiperidine derivatives 3a-f were conveniently prepared from trans-4-hydroxy-l-proline and applied to the catalytic enantioselective addition of diethylzinc to benzaldehyde and heptanal. Among them, 3d was found to show